Drug Details

General Information of the Drug (ID: DR5892)
Name
GSK2041706
Synonyms
GPR119 agonist; 1037779-47-7; SCHEMBL2370813; ZINC95929383; 5-[4-[(2R)-4-(3-fluoro-4-methylsulfonylphenoxy)butan-2-yl]piperidin-1-yl]-3-propan-2-yl-1,2,4-oxadiazole
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Molecular Type
Small molecule
Disease Type 2 diabetes mellitus [ICD-11: 5A11] Investigative [1]
Structure
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2D MOL

3D MOL

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Formula
C21H30FN3O4S
PubChem CID
24964226
Canonical SMILES
CC(C)C1=NOC(=N1)N2CCC(CC2)C(C)CCOC3=CC(=C(C=C3)S(=O)(=O)C)F
InChI
1S/C21H30FN3O4S/c1-14(2)20-23-21(29-24-20)25-10-7-16(8-11-25)15(3)9-12-28-17-5-6-19(18(22)13-17)30(4,26)27/h5-6,13-16H,7-12H2,1-4H3/t15-/m1/s1
InChIKey
AJJISMLYIMQAKP-OAHLLOKOSA-N
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Metformin      Galega officinalis     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [1]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Diet-induced obese (DIO) mouse models were used in this study.
                    Experimental
                    Result(s)		 The combination of GSK2041706 with metformin caused greater reductions in cumulative food intake (22.2% at 30 mg/kg and 37.5% at 100 mg/kg) and higher fed plasma glucagon-like peptide 1 and peptide tyrosine tyrosine levels and decreased plasma insulin and glucose-dependent insulinotropic polypeptide levels compared with their monotherapy groups.
Target and Pathway
Target(s) Programmed cell death protein 5 (PDCD5)  Molecule Info  [2]
References
Reference 1 Synergistic Effects of a GPR119 Agonist with Metformin on Weight Loss in Diet-Induced Obese Mice. J Pharmacol Exp Ther. 2015 Jun;353(3):496-504.
Reference 2 Synergistic antitumoral efficacy of a novel replicative adenovirus SG611-PDCD5 and daunorubicin in human leukemic cells. Onco Targets Ther. 2018 Aug 23;11:5121-5132.
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