Drug Details

General Information of the Drug (ID: DR5996)
Name
Sulindac sulfone
Synonyms
Aposulind; Aptosyn; FGN-1; Prevatac (former Brand Name); Exisulind; (Z)-5-Fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-indene-3-acetic acid
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Molecular Type
Small molecule
Disease Colorectal cancer [ICD-11: 2B91] Phase 3 [1]
Structure
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2D MOL

3D MOL

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Formula
C20H17FO4S
PubChem CID
5472495
Canonical SMILES
CC1=C(C2=C(C1=CC3=CC=C(C=C3)S(=O)(=O)C)C=CC(=C2)F)CC(=O)O
InChI
1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
InChIKey
MVGSNCBCUWPVDA-MFOYZWKCSA-N
CAS Number
CAS 59973-80-7
TTD Drug ID
D0M9VE
DrugBank ID
DB06246
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Curcumin      Hellenia speciosa     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Biological
                    Regulation		 Induction Cell cycle arrest in G2/M phase
                    In-vitro Model HT-29 CVCL_0320 Colon adenocarcinoma Homo sapiens
                    In-vivo Model Aberrant crypt foci (ACF) were induced male Wistar rats (6-week old) with DMH.
                    Experimental
                    Result(s)		 Curcumin potentiates the pro-apoptotic effects of sulindac sulfone in colorectal cancer.
Target and Pathway
Target(s) Phosphodiesterase 5A (PDE5A)  Molecule Info  [3]
KEGG Pathway Purine metabolism Click to Show/Hide
2 cGMP-PKG signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway Click to Show/Hide
Reactome cGMP effects Click to Show/Hide
References
Reference 1 ClinicalTrials.gov (NCT00085826) A Phase III Study of the Efficacy of Taxotere/Aptosyn Versus Taxotere/Placebo in Non-Small Cell Lung Cancer Patients. U.S. National Institutes of Health.
Reference 2 Curcumin potentiates the pro-apoptotic effects of sulindac sulfone in colorectal cancer. Expert Opin Investig Drugs. 2010 Apr;19 Suppl 1:S117-24.
Reference 3 Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. Cancer Res. 2000 Jul 1;60(13):3338-42.
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