Drug Details
| General Information of the Drug (ID: DR6969) | ||||
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| Name |
Platinum
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| Synonyms |
Precision tolerogens (autoimmune disease), NaniRx
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| Molecular Type |
Small molecule
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| Disease | Diabetes mellitus [ICD-11: 5A10] | Investigative | [1] | |
| Structure |
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| Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | ||||
| Formula |
Pt
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| PubChem CID | ||||
| Canonical SMILES |
[Pt]
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| InChI |
1S/Pt
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| InChIKey |
BASFCYQUMIYNBI-UHFFFAOYSA-N
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| CAS Number |
CAS 7440-06-4
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| GDSC | ||||
| TTD Drug ID | ||||
| DrugBank ID | ||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Hesperetin | Citrus limon | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| Molecule(s)
Regulation |
Down-regulation | Expression | UGT1A6 | Molecule Info |
Pathway MAP
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| In-vitro Model | A-549 | CVCL_0023 | Lung adenocarcinoma | Homo sapiens | ||
| LL/2 (LLC1) | CVCL_4358 | Malignant tumors | Mus musculus | |||
| In-vivo Model | Xenograft tumors were established by subcutaneous injection of 1*106 LLC cells into 6-week-old male C57BL/6 mice. | |||||
| Experimental
Result(s) |
Hesperetin can synergize platinum drugs by inhibiting UGT1A3 and increasing levels of reactive oxygen species (ROS). | |||||
