Drug Details

General Information of the Drug (ID: DR7720)
Name
HLM006474
Synonyms
HLM006474; 353519-63-8; 7-[(4-ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-8-quinolinol; 7-[(4-ethoxy-3-methylphenyl)-(pyridin-2-ylamino)methyl]-2-methylquinolin-8-ol; 7-[(4-ethoxy-3-methylphenyl)(pyridin-2-ylamino)methyl]-2-methylquinolin-8-ol; Oprea1_498948; SCHEMBL9963974; CHEMBL4571419; BCP34559; EX-A3531; 3384AH; CCG-21518; s8963; STK509159; AKOS000357958; AKOS022004575; CS-3180; HLM 006474; MCULE-1162226397; NCGC00387261-01; HY-16667; EU-0079871; HLM006474, >=98% (HPLC); HLM-006474; HLM 006474; SR-01000502837; SR-01000502837-1
    Click to Show/Hide
Molecular Type
Small molecule
Disease Melanoma [ICD-11: 2C30] Investigative [1]
Structure
Click to Download Mol
2D MOL

3D MOL

    Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product
Formula
C25H25N3O2
PubChem CID
2895500
Canonical SMILES
CCOC1=C(C=C(C=C1)C(C2=C(C3=C(C=CC(=N3)C)C=C2)O)NC4=CC=CC=N4)C
InChI
1S/C25H25N3O2/c1-4-30-21-13-11-19(15-16(21)2)23(28-22-7-5-6-14-26-22)20-12-10-18-9-8-17(3)27-24(18)25(20)29/h5-15,23,29H,4H2,1-3H3,(H,26,28)
InChIKey
CYNZBLNMIJNBSF-UHFFFAOYSA-N
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Paclitaxel      Taxus brevifolia     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Up-regulation Expression E2F3  Molecule Info 
Pathway MAP
                    In-vitro Model NCI-H1299 CVCL_0060 Lung large cell carcinoma Homo sapiens
NCI-H292 CVCL_0455 Lung mucoepidermoid carcinoma Homo sapiens
                    Experimental
                    Result(s)		 E2F inhibition synergizes with paclitaxel in lung cancer cell lines.
Target and Pathway
Target(s) Carbonic anhydrase IX (CA-IX)  Molecule Info  [3]
KEGG Pathway Nitrogen metabolism Click to Show/Hide
Pathway Interaction Database HIF-1-alpha transcription factor network Click to Show/Hide
Reactome Regulation of gene expression by Hypoxia-inducible Factor Click to Show/Hide
2 Reversible hydration of carbon dioxide
WikiPathways Vitamin D Receptor Pathway Click to Show/Hide
2 Reversible Hydration of Carbon Dioxide
3 Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
References
Reference 1 A small-molecule E2F inhibitor blocks growth in a melanoma culture model. Cancer Res. 2008 Aug 1;68(15):6292-9.
Reference 2 E2F inhibition synergizes with paclitaxel in lung cancer cell lines. PLoS One. 2014 May 15;9(5):e96357.
Reference 3 Combined 3-O-acetylbetulin treatment and carbonic anhydrase IX inhibition results in additive effects on human breast cancer cells. Chem Biol Interact. 2021 Jan 5;333:109326.
 Download Picture         KEGG Link