Drug Details

General Information of the Drug (ID: DR7799)
Name
Sulfinosine
Synonyms
2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purine-6-sulfinamide; 2-Amino-9-beta-ribofuranosylpurine-6-sulfinamide; SCHEMBL6907463; 9H-Purine-6-sulfinamide, 2-amino-9-beta-D-ribofuranosyl-; DTXSID70924860; 2-amino-9-beta-d-ribofuranosylpurine-6-sulfinamide; 2-Amino-9-beta-D-ribofuranosyl-9H-purine-6-sulfinamide; 2-Imino-9-pentofuranosyl-3,9-dihydro-2H-purine-6-sulfinamide
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Molecular Type
Small molecule
Disease Lung cancer [ICD-11: 2C25] Investigative [1]
Structure
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2D MOL

3D MOL

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Formula
C10H14N6O5S
PubChem CID
130209
Canonical SMILES
C1=NC2=C(N1C3C(C(C(O3)CO)O)O)N=C(N=C2S(=O)N)N
InChI
1S/C10H14N6O5S/c11-10-14-7-4(8(15-10)22(12)20)13-2-16(7)9-6(19)5(18)3(1-17)21-9/h2-3,5-6,9,17-19H,1,12H2,(H2,11,14,15)/t3-,5-,6-,9-,22?/m1/s1
InChIKey
NIXVOFULDIFBLB-QVRNUERCSA-N
CAS Number
CAS 124508-99-2
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Curcumin      Hellenia speciosa     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Expression GSTP1  Molecule Info 
Pathway MAP
Down-regulation Expression TOP2A  Molecule Info 
Pathway MAP
                    Biological
                    Regulation		 Induction Cell cycle arrest in S and G2/M phase
                    In-vitro Model NCI-H460 CVCL_0459 Lung large cell carcinoma Homo sapiens
                    Experimental
                    Result(s)		 Sulfinosine and curcumin overcome MDR in non-small cell lung carcinoma cell line (NSCLC) by regulating the expression of MDR-related genes mdr1, gst-pi and topo Iialpha.
References
Reference 1 Sulfinosine-induced cell growth inhibition and apoptosis in human lung carcinomas in vitro. Invest New Drugs. 2002 Aug;20(3):229-40.
Reference 2 Synergistic effects of the purine analog sulfinosine and curcumin on the multidrug resistant human non-small cell lung carcinoma cell line (NCI-H460/R). Cancer Biol Ther. 2008 Jul;7(7):1024-32.
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