Drug Details
| General Information of the Drug (ID: DR8626) | ||||
|---|---|---|---|---|
| Name |
GM-CSF
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| Molecular Type |
Protein
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| Disease | Acute myelogenous leukemia [ICD-11: 2A41] | Approved | [1] | |
| DrugBank ID | ||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Arsenic trioxide | Realgar and orpiment | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Up-regulation | Phosphorylation | JAK-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | PML | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | RARA | Molecule Info |
Pathway MAP
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| In-vitro Model | NB4 | CVCL_0005 | Acute promyelocytic leukemia | Homo sapiens | ||
| UF-1 | CVCL_0567 | Acute promyelocytic leukemia | Homo sapiens | |||
| In-vivo Model | Human GM-CSF-producing trans genic SCID (hGMTgSCID) mice were pretreated with 3 Gy of total body irradiation and then inoculated subcutaneously with UF-1 cells (1 * 107 cells) in their logarithmic growth phase. | |||||
| Experimental
Result(s) |
A combination of As2O3 and GM-CSF induces differentiation of APL cells both in vitro and in vivo. | |||||
| Target and Pathway | ||||
|---|---|---|---|---|
| Target(s) | GMCSFR-alpha (CSF2RA) | Molecule Info | [3] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | Click to Show/Hide | ||
| 2 | Jak-STAT signaling pathway | |||
| 3 | Hematopoietic cell lineage | |||
| 4 | Pathways in cancer | |||
| NetPath Pathway | IL3 Signaling Pathway | Click to Show/Hide | ||
| 2 | RANKL Signaling Pathway | |||
| Pathway Interaction Database | GMCSF-mediated signaling events | Click to Show/Hide | ||
| 2 | Alpha9 beta1 integrin signaling events | |||
| Reactome | GPVI-mediated activation cascade | Click to Show/Hide | ||
| 2 | G beta:gamma signalling through PI3Kgamma | |||
| 3 | Interleukin-3, 5 and GM-CSF signaling | |||
| 4 | RAF/MAP kinase cascade | |||
| 5 | Surfactant metabolism | |||
| 6 | Interleukin receptor SHC signaling | |||
| WikiPathways | Interleukin-2 signaling | Click to Show/Hide | ||
| 2 | Interleukin-3, 5 and GM-CSF signaling | |||
