Drug Details

General Information of the Drug (ID: DR8662)
Name
PFK15
Synonyms
PFK-015; 4382-63-2; PFK15; 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one; CHEMBL3105836; (E)-1-pyridin-4-yl-3-quinolin-2-ylprop-2-en-1-one; 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one; PFK 15; PFK015; SCHEMBL2702934; SCHEMBL16534534; AOB4632; SYN5216; BCP10875; EX-A4218; 2649AH; BDBM50445946; s7289; AKOS025287166; ZINC103235314; ACN-050165; CCG-267056; NCGC00386328-09; AC-28651; AS-16574; HY-12204; SW219876-1; A14287; (E)-1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one; 2314451-67-5
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Molecular Type
Small molecule
Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z] Investigative [1]
Structure
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2D MOL

3D MOL

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Formula
C17H12N2O
PubChem CID
25142799
Canonical SMILES
C1=CC=C2C(=C1)C=CC(=N2)C=CC(=O)C3=CC=NC=C3
InChI
1S/C17H12N2O/c20-17(14-9-11-18-12-10-14)8-7-15-6-5-13-3-1-2-4-16(13)19-15/h1-12H/b8-7+
InChIKey
UJJUKZPBUMCSJZ-BQYQJAHWSA-N
TTD Drug ID
D0A8AL
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Metformin      Galega officinalis     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Expression PFKFB3  Molecule Info 
Pathway MAP
                    In-vitro Model RPMI-8226 CVCL_0014 Plasma cell myeloma Homo sapiens
OPM-2 CVCL_1625 Plasma cell myeloma Homo sapiens
                    Experimental
                    Result(s)		 The synergistic effect of PFK15 with metformin exerts anti-myeloma activity via PFKFB3.
References
Reference 1 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
Reference 2 The synergistic effect of PFK15 with metformin exerts anti-myeloma activity via PFKFB3. Biochem Biophys Res Commun. 2019 Jul 23;515(2):332-338.
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