Drug Details
| General Information of the Drug (ID: DR9419) | ||||
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| Name |
Nystatin
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| Synonyms |
nystatin; Stamycin; Nilstat; Mycostatin; Biofanal; Diastatin; Moronal; Nystex; Nystatin A1; 1400-61-9; Nistatin; Nyotran; Nystavescent; Myconystatin; Mykostatyna; Nystatinum; Terrastatin; Herniocid; Mykinac; Nystatyna; Nyamyc; Nystan; Nystop; Candio-hermal; Candex Lotion; Zydin E; Mycostatin 20; Nystatin (Fungicidin); Barstatin 100; Mycostatin Pastilles; Nystatyna [Polish]; Moronal (antibiotic); Caswell No. 607B; Nystatin LF (liposome); Nystatine [INN-French]; Nystatinum [INN-Latin]; Nistatina [INN-Spanish]; Nystatin A; HSDB 3138; Nystatin A1, A2, A3 complex; (4E,6E,8E,10E,14E,16E,18S,19R,20R,21S,35S)-3-[(2S,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-19,25,27,29,32,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,14,16-hexaene-38-carboxylic acid; EINECS 215-749-0; EPA Pesticide Chemical Code 202800; NSC 150817; AI3-26526; AV & NYS; Nystatin + Aloe Vera Extract; SCHEMBL284974; Nystatin [USP:INN:BAN:JAN]; CHEBI:473992; (Liposomal Nystatin)Nyotrantrade mark; AKOS016339654; DB00646; KS-1373; (1S,15S,16R,17R,18S,19E,21E,25E,27E,29E,31E)-33-[(3-amino-3,6-dideoxy-a-D-mannopyranosyl)oxy]-1,3,4,7,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid; (1S,15S,16R,17R,18S,19E,21E,25E,27E,29E,31E)-33-[(3-amino-3,6-dideoxy-alpha-D-mannopyranosyl)oxy]-1,3,4,7,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid
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| Molecular Type |
Small molecule
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| Disease | Fungal infection [ICD-11: 1F29-1F2F] | Approved | [1] | |
| Structure |
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Click to Download Mol2D MOL |
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| Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | ||||
| Formula |
C47H75NO17
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| PubChem CID | ||||
| Canonical SMILES |
CC1C=CC=CCCC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(C(CCC(CC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O
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| InChI |
1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31?,32?,33?,34?,35?,36?,37?,38?,40?,41-,42+,43+,44-,46+,47+/m0/s1
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| InChIKey |
VQOXZBDYSJBXMA-RKEBNKJGSA-N
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| CAS Number |
CAS 1400-61-9
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| ChEBI ID | ||||
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| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Menthol | Mentha x piperita | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| In-vitro Model | Candida glabrata ATCC 90030 | Microorganism model | Candida glabrata | |||
| Candida krusei ATCC 6258 | Microorganism model | Candida krusei | ||||
| Experimental
Result(s) |
Synergistic anticandidal activity of menthol in combination with itraconazole and nystatin against clinical Candida glabrata and Candida krusei isolates. | |||||
| Target and Pathway | ||||
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| Target(s) | Fungal Cell membrane ergosterol (Fung CME) | Molecule Info | [3] | |
