Natural Product (NP) Details

General Information of the NP (ID: NP0868)
Name
Polyphyllin VII
Species Origin Paris polyphylla var. chinensis ...     Click to Show/Hide
Paris polyphylla var. chinensis
SuperKingdom: Eukaryota
Kingdom: Viridiplantae
Phylum: Tracheophyta
Class: Liliopsida
Order: Liliales
Family: Melanthiaceae
Genus: Paris
Species: Paris polyphylla var. chinensis
Disease Prostate cancer [ICD-11: 2C82] Investigative
Structure
Click to Download Mol
2D MOL

3D MOL

ADMET Property
Absporption
Caco-2 Permeability
 -7.036
 
MDCK Permeability
 -4.943
 
PAMPA
 +++
 
HIA
 +++
 
Distribution
VDss
 -0.531
 
PPB
 27.5%
 
BBB
 - - -
 
Metabolism
CYP1A2 inhibitor
 - - -
CYP1A2 substrate
 - - -
CYP2C19 inhibitor
 - - -
CYP2C19 substrate
 +++
CYP2C9 inhibitor
 - - -
CYP2C9 substrate
 +++
CYP2D6 inhibitor
 - - -
CYP2D6 substrate
 - - -
CYP3A4 inhibitor
 - - -
CYP3A4 substrate
 - - -
CYP2B6 inhibitor
 - - -
CYP2B6 substrate
 - - -
CYP2C8 inhibitor
 - - -
HLM Stability
 - - -
 
Excretion
CLplasma
 -0.113
 
T1/2
 3.505
Toxicity
DILI
 - -
 
Rat Oral Acute Toxicity
 - -
 
FDAMDD
 - -
 
Respiratory
 - - -
 
Human Hepatotoxicity
 +
 
Ototoxicity
 +++
 
Drug-induced Nephrotoxicity
 - - -
 
Drug-induced Neurotoxicity
 -
 
Hematotoxicity
 - - -
 
Genotoxicity
 - - -
 
Tips: 1. For the classification endpoints, the prediction probability values are transformed into six symbols: 0-0.1 (- - -), 0.1-0.3 (- -), 0.3-0.5 (-), 0.5-0.7 (+), 0.7-0.9 (++), and 0.9-1.0 (+++). 2. Additionally, the corresponding relationships of the three labels are as follows: excellent; medium; poor.
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PubChem CID
275155190
Target and Pathway
Target(s) Cystine/glutamate transporter (SLC7A11)  Molecule Info 
Glutathione peroxidase 4 (GPX4)  Molecule Info