Natural Product (NP) Details

General Information of the NP (ID: NP0904)
Name
Ginsenoside
Species Origin Panax ginseng ...     Click to Show/Hide
Panax ginseng
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Apiales
Family: Araliaceae
Genus: Panax
Species: Panax ginseng
Lepidine ( Lepidium sativum)
SuperKingdom: Eukaryota
Kingdom: Plantae
Phylum: Tracheophyta
Class: Magnoliopsida
Order: Brassicales
Family: Brassicaceae
Genus: Lepidium
Species: L. sativum
Disease Lung cancer [ICD-11: 2C25] Phase 2 [1]
Colon cancer [ICD-11: 2B90] Investigative
ADMET Property
Absporption
Caco-2 Permeability
 -4.959
 
MDCK Permeability
 -4.903
 
PAMPA
 +
 
HIA
 - - -
 
Distribution
VDss
 -0.198
 
PPB
 95.3%
 
BBB
 +++
 
Metabolism
CYP1A2 inhibitor
 - - -
CYP1A2 substrate
 - -
CYP2C19 inhibitor
 - - -
CYP2C19 substrate
 +++
CYP2C9 inhibitor
 - -
CYP2C9 substrate
 - -
CYP2D6 inhibitor
 - - -
CYP2D6 substrate
 - - -
CYP3A4 inhibitor
 - - -
CYP3A4 substrate
 +
CYP2B6 inhibitor
 -
CYP2B6 substrate
 - - -
CYP2C8 inhibitor
 ++
HLM Stability
 - -
 
Excretion
CLplasma
 13.497
 
T1/2
 0.468
Toxicity
DILI
 - - -
 
Rat Oral Acute Toxicity
 -
 
FDAMDD
 -
 
Respiratory
 ++
 
Human Hepatotoxicity
 +
 
Ototoxicity
 +
 
Drug-induced Nephrotoxicity
 +
 
Drug-induced Neurotoxicity
 - -
 
Hematotoxicity
 - -
 
Genotoxicity
 - -
 
Tips: 1. For the classification endpoints, the prediction probability values are transformed into six symbols: 0-0.1 (- - -), 0.1-0.3 (- -), 0.3-0.5 (-), 0.5-0.7 (+), 0.7-0.9 (++), and 0.9-1.0 (+++). 2. Additionally, the corresponding relationships of the three labels are as follows: excellent; medium; poor.
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Herb ID
HBIN027694
SymMap ID
SMIT02068
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Reorafenib      Colorectal cancer     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Expression BIRC5  Molecule Info 
Pathway MAP
Up-regulation Cleavage CASP3  Molecule Info 
Pathway MAP
                    In-vitro Model Hep-G2 CVCL_0027 Hepatocellular carcinoma Homo sapiens
                    Experimental
                    Result(s)		 The synergistic inhibitory effect presented by the combination therapy was dependent on the gradient concentration and treatment time.
          Cyclophosphamide      Solid tumour/cancer     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [3]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model C57BL/6 mice were inoculated by subcutaneous injection in the right front axilla with 1 * 106 Lewis cells.
                    Experimental
                    Result(s)		 Combination of Ginsenoside H dripping pills and cyclophosphamide improve paraneoplastic syndrome and inhibit postoperative recurrence via the reversion of Th1/Th2 shift.
Target and Pathway
Target(s) Protein kinase C beta (PRKCB)  Molecule Info  [4]
KEGG Pathway MAPK signaling pathway Click to Show/Hide
2 ErbB signaling pathway
3 Ras signaling pathway
4 Rap1 signaling pathway
5 Calcium signaling pathway
6 Chemokine signaling pathway
7 NF-kappa B signaling pathway
8 HIF-1 signaling pathway
9 Phosphatidylinositol signaling system
10 Sphingolipid signaling pathway
11 mTOR signaling pathway
12 Vascular smooth muscle contraction
13 Wnt signaling pathway
14 VEGF signaling pathway
15 Focal adhesion
16 Tight junction
17 Gap junction
18 Natural killer cell mediated cytotoxicity
19 B cell receptor signaling pathway
20 Fc epsilon RI signaling pathway
21 Fc gamma R-mediated phagocytosis
22 Leukocyte transendothelial migration
23 Circadian entrainment
24 Long-term potentiation
25 Retrograde endocannabinoid signaling
26 Glutamatergic synapse
27 Cholinergic synapse
28 Serotonergic synapse
29 GABAergic synapse
30 Dopaminergic synapse
31 Long-term depression
32 Inflammatory mediator regulation of TRP channels
33 Insulin secretion
34 GnRH signaling pathway
35 Melanogenesis
36 Thyroid hormone synthesis
37 Thyroid hormone signaling pathway
38 Oxytocin signaling pathway
39 Aldosterone-regulated sodium reabsorption
40 Endocrine and other factor-regulated calcium reabsorption
41 Salivary secretion
42 Gastric acid secretion
43 Pancreatic secretion
44 Carbohydrate digestion and absorption
45 Amphetamine addiction
46 Morphine addiction
47 Vibrio cholerae infection
48 Leishmaniasis
49 African trypanosomiasis
50 Amoebiasis
51 Hepatitis B
52 Influenza A
53 Pathways in cancer
54 Proteoglycans in cancer
55 MicroRNAs in cancer
56 Glioma
57 Non-small cell lung cancer
58 Choline metabolism in cancer
NetPath Pathway IL2 Signaling Pathway Click to Show/Hide
Panther Pathway Alzheimer disease-amyloid secretase pathway Click to Show/Hide
2 Angiogenesis
3 Apoptosis signaling pathway
4 B cell activation
5 EGF receptor signaling pathway
6 Endothelin signaling pathway
7 FGF signaling pathway
8 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
9 Inflammation mediated by chemokine and cytokine signaling pathway
10 Metabotropic glutamate receptor group I pathway
11 Muscarinic acetylcholine receptor 1 and 3 signaling pathway
12 VEGF signaling pathway
13 Wnt signaling pathway
14 5HT2 type receptor mediated signaling pathway
15 Histamine H1 receptor mediated signaling pathway
16 Oxytocin receptor mediated signaling pathway
17 Thyrotropin-releasing hormone receptor signaling pathway
18 CCKR signaling map ST
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells Click to Show/Hide
2 TCR signaling in na&#xef
3
4 TCR signaling in na&#xef
5
6 IL2-mediated signaling events
7 Ras signaling in the CD4+ TCR pathway
8 JNK signaling in the CD4+ TCR pathway
9 Regulation of Ras family activation
10 Downstream signaling in na&#xef
Reactome Disinhibition of SNARE formation Click to Show/Hide
2 Activation of NF-kappaB in B cells
3 Trafficking of GluR2-containing AMPA receptors
4 G alpha (z) signalling events
5 Depolymerisation of the Nuclear Lamina
6 WNT5A-dependent internalization of FZD4
7 VEGFR2 mediated cell proliferation
8 Response to elevated platelet cytosolic Ca2+
WikiPathways Calcium Regulation in the Cardiac Cell Click to Show/Hide
2 Insulin Signaling
3 EGF/EGFR Signaling Pathway
4 Wnt Signaling Pathway
5 Wnt Signaling Pathway and Pluripotency
6 MAPK Signaling Pathway
7 Wnt Signaling Pathway Netpath
8 G Protein Signaling Pathways
9 Kit receptor signaling pathway
10 Myometrial Relaxation and Contraction Pathways
11 Signaling by the B Cell Receptor (BCR)
12 Oncostatin M Signaling Pathway
13 Corticotropin-releasing hormone
14 AGE/RAGE pathway
15 B Cell Receptor Signaling Pathway
16 Signaling Pathways in Glioblastoma
17 miRs in Muscle Cell Differentiation
18 Response to elevated platelet cytosolic Ca2+
19 MicroRNAs in cardiomyocyte hypertrophy
20 Physiological and Pathological Hypertrophy of the Heart
References
Reference 1 ClinicalTrials.gov (NCT02714608) A Study of Ginsenoside H Dripping Pills for Advanced Non-Small Cell Lung Cancer (NSCLC)
Reference 2 Regorafenib and ginsenoside combination therapy: inhibition of HepG2 cell growth through modulating survivin and caspase-3 gene expression. Clin Transl Oncol. 2020 Sep;22(9):1491-1498.
Reference 3 Combination of Ginsenoside H dripping pills and cyclophosphamide improve paraneoplastic syndrome and inhibit postoperative recurrence via the reversion of Th1/Th2 shift. Biomed Pharmacother. 2018 Dec;108:865-875.
Reference 4 circ-PRKCB acts as a ceRNA to regulate p66Shc-mediated oxidative stress in intestinal ischemia/reperfusion. Theranostics. 2020 Aug 29;10(23):10680-10696.
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