Natural Product (NP) Details
| General Information of the NP (ID: NP1946) | |||||
|---|---|---|---|---|---|
| Name |
Dehydrocostus lactone
|
||||
| Synonyms |
Dehydrocostus lactone; dehydrocostuslactone; 477-43-0; (-)-dehydrocostus lactone; (-)-dehydrocostuslactone; CHEBI:244418; (3aS,6aR,9aR,9bS)-decahydro-3,6,9-tris(methylene)azuleno[4,5-b]furan-2(3H)-one; (3aR,6aS,9aS,9bR)-3,6,9-tris(methylidene)octahydroazuleno[4,5-b]furan-2,8(3H,4H)-dione; (3aS,6aR,9aR,9bS)-3,6,9-trimethylenedecahydroazuleno[4,5-b]furan-2(3H)-one; (3aS,6aR,9aR,9bS)-3,6,9-Trimethylenedecahydroazuleno[4,5-b]furan-2(9bH)-one; Dehydrocostus-Lactone; UNII-71TRF5K040; Epiligulyl oxide; CHEMBL88985; SCHEMBL699070; DTXSID80891554; 71TRF5K040; ZINC898477; Azuleno(4,5-b)furan-2(3H)-one, decahydro-3,6,9-tris(methylene)-, (3aS-(3a.alpha.,6a.alpha.,9a.alpha.,9b.beta.))-; Dehydro-costus lactone (6CI,7CI); EBD10311; HY-N0591; BDBM50370831; s3615; AKOS015896789; CCG-208469; CS-3636; MCULE-3657815830; Dehydrocostus lactone, >=98% (HPLC); NCGC00385838-01; (3aS,6aR,9aR,9bS)-3,6,9-trimethylene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one; AK168191; Dehydrocostus lactone, analytical standard; D5366; A14809; C09387; 299D482; Q27105152; (-)-Dehydrocostus lactone; Dehydrocostus lactone; Epiligulyl oxide; (3aR,6aS,9aS,9bR)-3,6,9-tris(methylene)octahydroazuleno[4,5-b]furan-2,8(3H,4H)-dione; (3aS,6aR,9aR,9bS)-Decahydro-3,6,9-tris(methylene)-azuleno[4,5-b]furan-2(3H)-one; Guaia-4(15),10(14),11(13)-trien-12-oic acid, 6alpha-hydroxy-, gamma-lactone; [3aS-(3aalpha,6aalpha,9aalpha,9bbeta)]-Decahydro-3,6,9-tris(methylene)-azuleno[4,5-b]furan-2(3H)-one; Azuleno(4,5-b)furan-2(3H)-one, decahydro-3,6,9-tris(methylene)-, (3aS-(3aalpha,6aalpha,9aalpha,9bbeta))-
Click to Show/Hide
|
||||
| Species Origin | Saussurea costus ... | Click to Show/Hide | |||
| Saussurea costus | |||||
| Disease | Laryngeal cancer [ICD-11: 2C23] | Investigative | [1] | ||
| Structure |
|
Click to Download Mol2D MOL |
|||
| Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | |||||
| Formula |
C15H18O2
|
||||
| PubChem CID | |||||
| Canonical SMILES |
C=C1CCC2C(C3C1CCC3=C)OC(=O)C2=C
|
||||
| InChI |
1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1
|
||||
| InChIKey |
NETSQGRTUNRXEO-XUXIUFHCSA-N
|
||||
| CAS Number |
CAS 477-43-0
|
||||
| ChEBI ID | |||||
| Herb ID | |||||
| SymMap ID | |||||
| TCMSP ID | |||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Doxorubicin | Solid tumour/cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
|
|||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
|
|
| Down-regulation | Expression | MMP-2 | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | MMP-9 | Molecule Info |
Pathway MAP
|
||
| In-vitro Model | NCI-H460 | CVCL_0459 | Lung large cell carcinoma | Homo sapiens | ||
| A-549 | CVCL_0023 | Lung adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
The putative mechanism behind the metastasis-limiting effects of DHC may involve the suppression of Akt/GSK-3Beta and inhibition of MMP-2 and MMP-9 in lung cancer cells. | |||||
| Target and Pathway | ||||
|---|---|---|---|---|
| Target(s) | Calmodulin-3 (NFATC1) | Molecule Info | [3] | |
