Natural Product (NP) Details
| General Information of the NP (ID: NP3833) | |||||
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| Name |
Anisodine
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| Synonyms |
anisodine; 52646-92-1; SCHEMBL474045; Q2033359; 2,3-Dihydroxy-2-phenylpropanoic acid 9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonane-7alpha-yl ester
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| Species Origin | Hyoscyamus niger ... | Click to Show/Hide | |||
| Hyoscyamus niger | |||||
| Disease | Mild neurocognitive disorder [ICD-11: 6D71] | Investigative | [1] | ||
| Structure |
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| Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | |||||
| Formula |
C17H21NO5
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| PubChem CID | |||||
| Canonical SMILES |
CN1C2CC(CC1C3C2O3)OC(=O)C(CO)(C4=CC=CC=C4)O
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| InChI |
1S/C17H21NO5/c1-18-12-7-11(8-13(18)15-14(12)23-15)22-16(20)17(21,9-19)10-5-3-2-4-6-10/h2-6,11-15,19,21H,7-9H2,1H3
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| InChIKey |
JEJREKXHLFEVHN-UHFFFAOYSA-N
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| Herb ID | |||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Cytidine-5'-diphosp-bocholine | Substance abuse | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| Experimental
Result(s) |
The combination of anisodine and citicoline with standard steroid and mannitol therapy appears to be effective in the treatment of early optic nerve contusion. | |||||
| β. A List of Drug(s) Whose Adverse Effect can be Decreased by This NP | ||||||
| Recombinant tissue plasminogen activator | Pulmonary thromboembolism | Click to Show/Hide the Molecular Data of This Drug | ||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [3] | |||||
| Detail(s) |
Combination Info
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| In-vivo Model | Clinical trial | |||||
| Experimental
Result(s) |
Intravenous thrombolysis with rt-PA combined with compound anisodine is safe and effective in treating CRAO, which can significantly improve the prognosis of patients. | |||||
