Natural Product (NP) Details

General Information of the NP (ID: NP6365)
Name
Phloretin
Synonyms
phloretin; 60-82-2; Dihydronaringenin; Phloretol; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone; MFCD00002288; 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-; NSC 407292; UNII-S5J5OE47MK; beta-(p-Hydroxyphenyl)phloropropiophenone; 2',4',6'-Trihydroxy-3-(p-hydroxyphenyl)propiophenone; 2',4',6'-Trihydroxy-3-(4-Hydroxyphenyl)propiophenone; C15H14O5; NSC407292; S5J5OE47MK; beta-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone; CHEMBL45068; CHEBI:17276; Phloretin, 98%; beta-(4-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone; 2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)-propiophenone; Propiophenone, 2',4',6'-trihydroxy-3-(p-hydroxyphenyl)-; 2',4,4',6'-Tetrahydroxydihydrochalcone; .beta.-(p-Hydroxyphenyl)phloropropiophenone; 2',4,4',6'-Tetrahydroxy-Dihydrochalcone; NSC 407292;RJC 02792; SMR000326783; CCRIS 7459; SR-01000076081; EINECS 200-488-7; Asebogenol; 2uxi; G50; Spectrum_001295; 4,2',4',6'-Tetrahydroxydihydrochalcone; Phloretin, >=99%; ACMC-209mmd; SpecPlus_000333; Spectrum2_000681; Spectrum3_001036; Spectrum4_001172; Spectrum5_001698; Lopac-P-7912; DSSTox_CID_2393; cid_4788; DSSTox_RID_76569; DSSTox_GSID_22393; Lopac0_001012; Oprea1_824722; REGID_for_CID_4788; SCHEMBL38131; BSPBio_002851; KBioGR_001803; KBioSS_001775; SPECTRUM300554; MLS000728507; MLS000859922; MLS006012024; BIDD:ER0174; DivK1c_006429; SPBio_000801; GTPL4285; DTXSID6022393; BCBcMAP01_000040; BDBM23446; KBio1_001373; KBio2_001775; KBio2_004343; KBio2_006911; KBio3_002071; Phloretin - CAS 60-82-2; ZINC47553; HMS2224N17; HMS3263K05; HMS3332J03; HMS3656I07; ACN-S003569; BCP28296; HY-N0142; TNP00255; Tox21_202854; Tox21_501012; ANW-33587; BBL027375; CCG-38573; CP0082; KM0437; LMPK12120525; O1P165; s2342; SBB066137; STL372996; AKOS015856338; AC-7995; ACN-035397; CS-1477; DB07810; LP01012; MCULE-3672992389; NSC-407292; SDCCGMLS-0066637.P001; SDCCGSBI-0050985.P003; CAS-60-82-2; Phloretin, analytical reference material; SMP1_000238; NCGC00015840-01; NCGC00015840-02; NCGC00015840-03; NCGC00015840-04; NCGC00015840-05; NCGC00015840-06; NCGC00015840-07; NCGC00015840-08; NCGC00015840-09; NCGC00015840-18; NCGC00094304-01; NCGC00094304-02; NCGC00094304-03; NCGC00094304-04; NCGC00260400-01; NCGC00261697-01; AK162403; AS-14100; ST057164; SY017103; AB0016775; DB-053714; EU-0101012; FT-0603256; N1316; P1966; SW219308-1; C00774; P 7912; 2',6'-Trihydroxy-3-(p-hydroxyphenyl)propiophenone; Q-100701; Q2268463; SR-01000076081-1; SR-01000076081-7; SR-01000076081-8; .beta.-(p-Hydroxyphenyl)-2,6-trihydroxypropiophenone; BRD-K15563106-001-02-4; BRD-K15563106-001-10-7; Propiophenone,4',6'-trihydroxy-3-(p-hydroxyphenyl)-; .beta.-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone; 1-(2,4,6-trihydroxyphenyl)-3-(4-hydroxyphenyl)-1-propanone; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanon; 3-(4-Hydroxy-phenyl)-1-(2,4,6-trihydroxy-phenyl)-propan-1-one; Propiophenone, 2',4',6'-trihydroxy-3-(p-hydroxyphenyl)- (8CI)
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Species Origin Prunus armeniaca ...     Click to Show/Hide
Prunus armeniaca
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Rosales
Family: Rosaceae
Genus: Prunus
Species: Prunus armeniaca
Disease Ulcerative colitis [ICD-11: DD71] Investigative [1]
Structure
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2D MOL

3D MOL

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Formula
C15H14O5
PubChem CID
4788
Canonical SMILES
C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O
InChI
1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
InChIKey
VGEREEWJJVICBM-UHFFFAOYSA-N
CAS Number
CAS 60-82-2
ChEBI ID
CHEBI:17276
Herb ID
HBIN039573
TTD Drug ID
D0HD2G
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Atorvastatin      Cardiovascular disease     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Expression CCNB1  Molecule Info 
Pathway MAP
Up-regulation Expression MYT1  Molecule Info 
Pathway MAP
Down-regulation Phosphorylation POLD1  Molecule Info 
Pathway MAP
                    In-vitro Model SW620 CVCL_0547 Colon adenocarcinoma Homo sapiens
HCT 116 CVCL_0291 Colon carcinoma Homo sapiens
                    Experimental
                    Result(s)		 Phloretin and Atorvastatin produce a powerful synergistic interaction in suppressing colon cancer cell growth. This process was accomplished via the synergistic induction of apoptosis and the arrest of the cell cycle at the G2/M checkpoint, which resulted from downregulated cdc2 activation following combined treatment.
    β. A List of Drug(s) Whose Adverse Effect can be Decreased by This NP
          Duloxetine      Depression     Click to Show/Hide the Molecular Data of This Drug
                 Decreasing Adverse Drug Reaction     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [3]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Diabetic neuropathy (DN) rat models were used in this study.
                    Experimental
                    Result(s)		 DX augmented the DM metabolic disturbance and hepatic dysfunction, however, PH effectively amended these disorders. The low-dose combination of both, had the merits of both medications, with the alleviation of their disadvantages.
Target and Pathway
Target(s) Aquaporin-9 (AQP9)  Molecule Info  [4]
Chloride channel protein 3 (CLC-3)  Molecule Info  [5]
Sodium-dependent vitamin C transporter 1 (SVCT1)  Molecule Info  [6]
References
Reference 1 Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota. Pharmacol Res. 2019 Dec;150:104489.
Reference 2 Synergistic inhibition of colon cancer cell growth by a combination of atorvastatin and phloretin. Oncol Lett. 2018 Feb;15(2):1985-1992.
Reference 3 Phloretin either alone or in combination with duloxetine alleviates the STZ-induced diabetic neuropathy in rats. Biomed Pharmacother. 2018 May;101:821-832.
Reference 4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 696).
Reference 5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 702).
Reference 6 A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature. 1999 May 6;399(6731):70-5.
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