Natural Product (NP) Details

General Information of the NP (ID: NP7425)
Name
Zinc oxide
Synonyms
ZINC OXIDE; 1314-13-2; oxozinc; Zinc White; Zinc oxide (ZnO); Zinc monoxide; Zinc Oxide Powder; MFCD00011300; Amalox; Chinese White; Snow white; Emanay zinc oxide; Felling zinc oxide; Akro-zinc bar 85; Flowers of zinc; Azo-33; Outmine; Supertah; Zincite; Zincoid; Azodox; Ozide; Ozlo; Zincum Oxydatum; Lassars Paste; Zinc oxide, ACS reagent; Flores de zinci; Lassar Paste; Zinci Oxicum; Zinci Oxydum; Hubbuck's White; Blanc de Zinc; Unichem ZO; Zinc oxide, 99.5+%; Vandem VAC; Vandem VOC; Vandem VPC; Green seal-8; Philosopher's wool; White seal-7; K-Zinc; ZNO; Powder base 900; Protox type 166; Protox type 167; Protox type 168; Protox type 169; Protox type 267; Protox type 268; Akro-zinc bar 90; Azodox-55; Azodox-55TT; Red Seal 9; EMAR; CI Pigment white 4; Electrox 2500; Actox 14; Actox 16; Kadox 15; Kadox 72; Kadox-25; Zinc oxide [USAN]; Zinca 20; Protox 166; Protox 168; Protox 169; Caswell No. 920; Electox 2500; Cadox XX 78; Actox 216; Cynku tlenek [Polish]; Desitin; Nogenol; C-Weiss 8 [German]; zincum oxidatum; Azo-55TT; Azo-66TT; Azo-77TT; Cynku tlenek; Zinc gelatin; C.I. Pigment White 4; oxyde de zinc; Zinc oxide fume; RVPaque; Azo 22; Azo-55; Azo-66; Azo-77; No-Genol; Zinc oxide substrate, 10x10x0.5mm, polished one side, 0001 orientation; Zinc oxide substrate, 10x10x0.5mm, polished two sides, 0001 orientation; Pigment white 4; C.I. 77947; Zinc oxide, 99.99% trace metals basis; GIAP 10; CCRIS 1309; C-Weiss 8; Zinc oxide, 99.999%, (trace metal basis); Zn 0701T; HSDB 5024; A&D Medicated Ointment; XX 78; EINECS 215-222-5; Zinc oxide [USP:JAN]; XX 203; XX 601; EPA Pesticide Chemical Code 088502; CI 77947; Zinkoxid; AI3-00277; oxido de cinc; Leaded zinc oxide; ZN-0401 E 3/16''; ZnO Quantum Dots; Zinc (as oxide); Zinc Oxide Slurry; Zinc oxide, heavy; Zinc oxide (TN); Zinc Oxide Nanowire; Zinc Oxide Nanowires; Zine Oxide ,(S); Zinc Oxide Dispersion; Zinc Oxide Nanopowder; Zinc oxide, Nanotek?; Zinc (as zinc oxide); Zinc Oxide Nanoparticle; Zinc oxide, Puratronic; Zinc Oxide Quantum Dots; EC 215-222-5; Zinc oxide (JP17/USP); Zinc oxide, sintered tablets; Zinc oxide, LR, >=99%; Aluminium Doped ZnO Dispersion; Zinc oxide [USAN:USP:JAN]; Zinc oxide, analytical standard; Zinc Oxide Nanopowder Dispersion; CHEBI:36560; Zinc Oxide Nanopowder (Type I); Zinc oxide, NanoArc ZN-0605; Zinc oxide, p.a., 99.0%; Zinc Oxide Nanopowder (Type II); Zinc Oxide Dispersion Wood Coating; Zinc Oxide Powder, 99.9% Nano; Yttrium Doped Zinc Oxide Dispersion; 9015AF; Europium Doped Zinc Oxide Dispersion; Zinc oxide, USP, 99-100.5%; AKOS015904168; Zinc Oxide Nanoparticles / Nanopowder; DB09321; Zinc oxide, ACS reagent, >=99.0%; Zinc oxide, 99.999% (metals basis); Zinc oxide, 30nm,20 wt.% isopropanol; Zinc oxide, tested according to Ph.Eur.; 8051-03-4; Zinc oxide, 99.999% trace metals basis; Zinc oxide, SAJ first grade, >=99.0%; Zinc oxide, JIS special grade, >=99.0%; FT-0631786; FT-0640838; FT-0645092; Antimony Tin Dioxide (ATO) Sputtering Targets; D01170; Zinc oxide, nanopowder, <100 nm particle size; Q190077; Zinc Oxide Nanodispersion Type A-Nonionic (70nm); Zinc Oxide Nanodispersion Type B-Anionic (70nm); Zinc Oxide Nanodispersion Type C-Cationic (70nm); Zinc oxide, nanowires, diam. x L 90 nm x 1 mum; J-005999; Zinc oxide, nanowires, diam. x L 50 nm x 300 nm; Zinc oxide, nanowires, diam. x L 300 nm x 4-5 mum; Zinc oxide, puriss. p.a., ACS reagent, >=99.0% (KT); AZO Powder / AZO MicroPowder / ZnO Doped with Metal Aluminum; Zinc oxide, nanopowder, <50 nm particle size (BET), >97%; Zinc oxide, ReagentPlus(R), powder, <5 mum particle size, 99.9%; Zinc oxide, United States Pharmacopeia (USP) Reference Standard; 20 wt% Zinc Oxide in water, 20 wt% (ZnO) (pale yellow powder), >99% Nano; Zinc oxide sputtering target, 50.8mm (2.0in) dia x 3.18mm (0.125in) thick; Zinc oxide sputtering target, 50.8mm (2.0in) dia x 6.35mm (0.250in) thick; Zinc oxide sputtering target, 76.2mm (3.0in) dia x 6.35mm (0.250in) thick; Zinc oxide, dispersion, nanoparticles, <110 nm particle size, 40 wt. % in butyl acetate; Zinc oxide, dispersion, nanoparticles, 40 wt. % in ethanol, <130 nm particle size; Zinc oxide, dispersion, nanoparticles, <100 nm particle size (TEM), <=40 nm avg. part. size (APS), 20 wt. % in H2O; Zinc oxide, NanoTek Z1102PMA, 50% in 1,2-propanediol monomethyl ether acetate, colloidal dispersion; Zinc oxide, puriss., meets analytical specification of Ph. Eur., BP, USP, 99-100.5% (calc. for dried substance); Zinc oxide, sputtering target, diam. x thickness 3.00 in. x 0.125 in., 99.99% trace metals basis
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Disease Chronic obstructive pulmonary disease [ICD-11: CA22] Investigative [1]
Structure
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2D MOL

3D MOL

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Formula
OZn
PubChem CID
14806
Canonical SMILES
O=[Zn]
InChI
1S/O.Zn
InChIKey
XLOMVQKBTHCTTD-UHFFFAOYSA-N
CAS Number
CAS 1314-13-2
ChEBI ID
CHEBI:36560
Herb ID
HBIN048986
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Ciprofloxacin + Ceftazidime     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vitro Model A. baumannii Microorganism model Acinetobacter baumannii
                    Experimental
                    Result(s)		 ZnO-NPs potentiate the antimicrobial action of ciprofloxacin and ceftazidime.
Target and Pathway
Target(s) Androgen receptor (AR)  Molecule Info  [3]
Caspase-3 (CASP3)  Molecule Info  [4]
Catalase (CAT)  Molecule Info  [5]
BioCyc Reactive oxygen species degradation Click to Show/Hide
2 Ethanol degradation IV
KEGG Pathway MAPK signaling pathway Click to Show/Hide
2 p53 signaling pathway
3 Apoptosis
4 Natural killer cell mediated cytotoxicity
5 TNF signaling pathway
6 Serotonergic synapse
7 Non-alcoholic fatty liver disease (NAFLD)
8 Alzheimer's disease
9 Parkinson's disease
10 Amyotrophic lateral sclerosis (ALS)
11 Huntington's disease
12 Epithelial cell signaling in Helicobacter pylori infection
13 Pertussis
14 Legionellosis
15 Toxoplasmosis
16 Amoebiasis
17 Tuberculosis
18 Hepatitis B
19 Herpes simplex infection
20 Pathways in cancer
21 Viral carcinogenesis
22 Proteoglycans in cancer
23 MicroRNAs in cancer
24 Colorectal cancer
25 Viral myocarditis
26 Oocyte meiosis
27 Prostate cancer
28 Tryptophan metabolism
29 Glyoxylate and dicarboxylate metabolism
30 Biosynthesis of antibiotics
31 FoxO signaling pathway
32 Peroxisome
NetPath Pathway TCR Signaling Pathway Click to Show/Hide
2 IL2 Signaling Pathway
3 IL4 Signaling Pathway
4 EGFR1 Signaling Pathway
5 AndrogenReceptor Signaling Pathway
6 FSH Signaling Pathway
Panther Pathway Apoptosis signaling pathway Click to Show/Hide
2 FAS signaling pathway
3 Huntington disease
4 CCKR signaling map ST
Pathwhiz Pathway Degradation of Superoxides Click to Show/Hide
2 Ethanol Degradation
3 Tryptophan Metabolism
Pathway Interaction Database LPA receptor mediated events Click to Show/Hide
2 Calcineurin-regulated NFAT-dependent transcription in lymphocytes
3 FAS (CD95) signaling pathway
4 Role of Calcineurin-dependent NFAT signaling in lymphocytes
5 Posttranslational regulation of adherens junction stability and dissassembly
6 p75(NTR)-mediated signaling
7 HIV-1 Nef: Negative effector of Fas and TNF-alpha
8 Caspase Cascade in Apoptosis
9 Syndecan-2-mediated signaling events
10 Regulation of nuclear SMAD2/3 signaling
11 Coregulation of Androgen receptor activity
12 Regulation of Androgen receptor activity
13 Nongenotropic Androgen signaling
14 Regulation of nuclear beta catenin signaling and target gene transcription
15 FOXA1 transcription factor network
16 Notch-mediated HES/HEY network
17 FoxO family signaling
Reactome SMAC binds to IAPs Click to Show/Hide
2 SMAC-mediated dissociation of IAP:caspase complexes
3 Apoptotic cleavage of cellular proteins
4 Degradation of the extracellular matrix
5 NADE modulates death signalling
6 Activation of DNA fragmentation factor
7 Caspase-mediated cleavage of cytoskeletal proteins
8 Nuclear Receptor transcription pathway
9 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
10 Detoxification of Reactive Oxygen Species
11 Purine catabolism
WikiPathways DNA Damage Response Click to Show/Hide
2 SIDS Susceptibility Pathways
3 Apoptosis Modulation by HSP70
4 MAPK Signaling Pathway
5 Copper homeostasis
6 FAS pathway and Stress induction of HSP regulation
7 Signaling by Hippo
8 Apoptosis
9 Amyotrophic lateral sclerosis (ALS)
10 Spinal Cord Injury
11 BDNF signaling pathway
12 Integrated Pancreatic Cancer Pathway
13 Oncostatin M Signaling Pathway
14 Parkinsons Disease Pathway
15 Corticotropin-releasing hormone
16 Allograft Rejection
17 AGE/RAGE pathway
18 TNF alpha Signaling Pathway
19 Prostate Cancer
20 Alzheimers Disease
21 TWEAK Signaling Pathway
22 Integrated Breast Cancer Pathway
23 Signalling by NGF
24 Integrated Cancer pathway
25 Regulation of Apoptosis
26 Intrinsic Pathway for Apoptosis
27 Apoptotic execution phase
28 Apoptosis Modulation and Signaling
29 miRNA Regulation of DNA Damage Response
30 Nuclear Receptors
31 Androgen receptor signaling pathway
32 DNA Damage Response (only ATM dependent)
33 Tryptophan metabolism
34 Oxidative Stress
35 Detoxification of Reactive Oxygen Species
36 Metabolism of nucleotides
37 Folate Metabolism
38 Selenium Micronutrient Network
References
Reference 1 Zinc oxide nanoparticle inhibits the biofilm formation of Streptococcus pneumoniae. Antonie Van Leeuwenhoek. 2018 Jan;111(1):89-99.
Reference 2 Antimicrobial action of zinc oxide nanoparticles in combination with ciprofloxacin and ceftazidime against multidrug-resistant Acinetobacter baumannii. J Glob Antimicrob Resist. 2016 Sep;6:118-122.
Reference 3 Self-Aligned Top-Gate Metal-Oxide Thin-Film Transistors Using a Solution-Processed Polymer Gate Dielectric. Micromachines (Basel). 2020 Nov 25;11(12):1035.
Reference 4 Zinc oxide nanoparticles induce human multiple myeloma cell death via reactive oxygen species and Cyt-C/Apaf-1/Caspase-9/Caspase-3 signaling pathway in vitro. Biomed Pharmacother. 2020 Feb;122:109712.
Reference 5 The antioxidant effects of silver, gold, and zinc oxide nanoparticles on male mice in in vivo condition. Adv Biomed Res. 2015 Mar 25;4:69.
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