Natural Product (NP) Details

General Information of the NP (ID: NP7659)
Name
Bovine lactoferrin
Species Origin Milk vetch dwarf China alphasatellite ...     Click to Show/Hide
Milk vetch dwarf China alphasatellite
SuperKingdom: Viruses
Family: Alphasatellitidae
Genus: Mivedwarsatellite
Species: Milk vetch dwarf China alphasatellite
Disease Diarrhea [ICD-11: ME05] Phase 2 [1]
ADMET Property
Absporption
Caco-2 Permeability
 -4.968
 
MDCK Permeability
 -4.646
 
PAMPA
 +++
 
HIA
 - - -
 
Distribution
VDss
 -0.102
 
PPB
 90.5%
 
BBB
 +++
 
Metabolism
CYP1A2 inhibitor
 - - -
CYP1A2 substrate
 - - -
CYP2C19 inhibitor
 - - -
CYP2C19 substrate
 - - -
CYP2C9 inhibitor
 - - -
CYP2C9 substrate
 - - -
CYP2D6 inhibitor
 - - -
CYP2D6 substrate
 - - -
CYP3A4 inhibitor
 +++
CYP3A4 substrate
 +++
CYP2B6 inhibitor
 - - -
CYP2B6 substrate
 - - -
CYP2C8 inhibitor
 - - -
HLM Stability
 - - -
 
Excretion
CLplasma
 6.011
 
T1/2
 0.813
Toxicity
DILI
 +++
 
Rat Oral Acute Toxicity
 -
 
FDAMDD
 ++
 
Respiratory
 ++
 
Human Hepatotoxicity
 ++
 
Ototoxicity
 ++
 
Drug-induced Nephrotoxicity
 +++
 
Drug-induced Neurotoxicity
 +++
 
Hematotoxicity
 -
 
Genotoxicity
 +++
 
Tips: 1. For the classification endpoints, the prediction probability values are transformed into six symbols: 0-0.1 (- - -), 0.1-0.3 (- -), 0.3-0.5 (-), 0.5-0.7 (+), 0.7-0.9 (++), and 0.9-1.0 (+++). 2. Additionally, the corresponding relationships of the three labels are as follows: excellent; medium; poor.
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Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Penicillin G      Syphilis     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Nineteen late-lactating cows had all 4 mammary quarters individually inoculated (185 cfu) through the teat cistern with the PG-resistant Staph. Aureus SHY97-4320.
                    Experimental
                    Result(s)		 BLF added to PG is an effective combination (i.e., 3- to 5-times higher cure rate) for the treatment of stable Staph. aureu infections highly resistant to beta-lactam antibiotics.
References
Reference 1 ClinicalTrials.gov (NCT02626104) Bovine Lactoferrin and Antibiotic-associated Diarrhoea.
Reference 2 Efficacy of a lactoferrin-penicillin combination to treat {beta}-lactam-resistant Staphylococcus aureus mastitis. J Dairy Sci. 2007 Jun;90(6):2778-87.
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