Natural Product (NP) Details

General Information of the NP (ID: NP8646)
Name
Arabinogalactan
Synonyms
Galactoarabinan; 9036-66-2; (+)-Arabinogalactan; ARABINOGALACTAN; 4-[6-[(3,5-dihydroxy-4-methoxyoxan-2-yl)oxymethyl]-3,5-dihydroxy-4-methoxyoxan-2-yl]oxy-2-(hydroxymethyl)-6-methyloxane-3,5-diol; ANW-42610; FT-0604415
    Click to Show/Hide
Species Origin Senegalia senegal ...     Click to Show/Hide
Senegalia senegal
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Fabales
Family: Fabaceae
Genus: Senegalia
Species: Senegalia senegal
Disease Elevated blood glucose [ICD-11: MA18] Phase 1 [1]
Structure
Click to Download Mol
2D MOL

3D MOL

ADMET Property
Absporption
Caco-2 Permeability
 -5.956
 
MDCK Permeability
 -5.196
 
PAMPA
 +++
 
HIA
 +++
 
Distribution
VDss
 -0.673
 
PPB
 24.9%
 
BBB
 - - -
 
Metabolism
CYP1A2 inhibitor
 - - -
CYP1A2 substrate
 - - -
CYP2C19 inhibitor
 - - -
CYP2C19 substrate
 +++
CYP2C9 inhibitor
 - - -
CYP2C9 substrate
 - - -
CYP2D6 inhibitor
 - - -
CYP2D6 substrate
 - - -
CYP3A4 inhibitor
 - - -
CYP3A4 substrate
 +++
CYP2B6 inhibitor
 - - -
CYP2B6 substrate
 - - -
CYP2C8 inhibitor
 - - -
HLM Stability
 - - -
 
Excretion
CLplasma
 0.33
 
T1/2
 3.198
Toxicity
DILI
 +
 
Rat Oral Acute Toxicity
 - -
 
FDAMDD
 - - -
 
Respiratory
 - - -
 
Human Hepatotoxicity
 -
 
Ototoxicity
 +++
 
Drug-induced Nephrotoxicity
 - - -
 
Drug-induced Neurotoxicity
 +
 
Hematotoxicity
 - - -
 
Genotoxicity
 - - -
 
Tips: 1. For the classification endpoints, the prediction probability values are transformed into six symbols: 0-0.1 (- - -), 0.1-0.3 (- -), 0.3-0.5 (-), 0.5-0.7 (+), 0.7-0.9 (++), and 0.9-1.0 (+++). 2. Additionally, the corresponding relationships of the three labels are as follows: excellent; medium; poor.
    Click to Show/Hide
    Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product
Formula
C20H36O14
PubChem CID
24847856
Canonical SMILES
CC1C(C(C(C(O1)CO)O)OC2C(C(C(C(O2)COC3C(C(C(CO3)O)OC)O)O)OC)O)O
InChI
1S/C20H36O14/c1-7-11(23)18(12(24)9(4-21)32-7)34-20-15(27)17(29-3)13(25)10(33-20)6-31-19-14(26)16(28-2)8(22)5-30-19/h7-27H,4-6H2,1-3H3
InChIKey
SATHPVQTSSUFFW-UHFFFAOYSA-N
CAS Number
CAS 9036-66-2
Herb ID
HBIN016561
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Rifaximin alpha      Hepatic fibrosis/cirrhosis     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Retrospective observational survey study
                    Experimental
                    Result(s)		 Combination therapy with cyclic rifaximin-Alpha and continuous arabinogalactan combined with lactoferrin are effective in SUDD treatment in terms of symptom resolution, bowel movement normalization, prevention of recurrences with very good patient's compliance.
References
Reference 1 ClinicalTrials.gov (NCT04005924) Effect of an Arabinogalactan Product
Reference 2 Combined therapy: rifaximin-Alpha and arabinogalactan with lactoferrin combination effectively prevents recurrences of symptomatic uncomplicated diverticular disease. Pol Przegl Chir. 2020 Apr 7;92(2):22-28.
 Download Picture         KEGG Link