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Natural Product (NP) Details

General Information of the NP (ID: NP8646)
Name
Arabinogalactan
Synonyms
Galactoarabinan; 9036-66-2; (+)-Arabinogalactan; ARABINOGALACTAN; 4-[6-[(3,5-dihydroxy-4-methoxyoxan-2-yl)oxymethyl]-3,5-dihydroxy-4-methoxyoxan-2-yl]oxy-2-(hydroxymethyl)-6-methyloxane-3,5-diol; ANW-42610; FT-0604415
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Species Origin Senegalia senegal ...     Click to Show/Hide
Senegalia senegal
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Fabales
Family: Fabaceae
Genus: Senegalia
Species: Senegalia senegal
Disease Elevated blood glucose [ICD-11: MA18] Phase 1 [1]
Structure
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2D MOL

3D MOL

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Formula
C20H36O14
PubChem CID
24847856
Canonical SMILES
CC1C(C(C(C(O1)CO)O)OC2C(C(C(C(O2)COC3C(C(C(CO3)O)OC)O)O)OC)O)O
InChI
1S/C20H36O14/c1-7-11(23)18(12(24)9(4-21)32-7)34-20-15(27)17(29-3)13(25)10(33-20)6-31-19-14(26)16(28-2)8(22)5-30-19/h7-27H,4-6H2,1-3H3
InChIKey
SATHPVQTSSUFFW-UHFFFAOYSA-N
CAS Number
CAS 9036-66-2
Herb ID
HBIN016561
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Rifaximin alpha      Hepatic fibrosis/cirrhosis     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Retrospective observational survey study
                    Experimental
                    Result(s)
Combination therapy with cyclic rifaximin-Alpha and continuous arabinogalactan combined with lactoferrin are effective in SUDD treatment in terms of symptom resolution, bowel movement normalization, prevention of recurrences with very good patient's compliance.
References
Reference 1 ClinicalTrials.gov (NCT04005924) Effect of an Arabinogalactan Product
Reference 2 Combined therapy: rifaximin-Alpha and arabinogalactan with lactoferrin combination effectively prevents recurrences of symptomatic uncomplicated diverticular disease. Pol Przegl Chir. 2020 Apr 7;92(2):22-28.
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Cite NPCDR
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Correspondence

X. N. Sun, Y. T. Zhang, Y. Zhou, X. C. Lian, L. L. Yan, T. Pan, T. Jin, H. Xie, Z. M. Liang, W. Q. Qiu, J. X. Wang, Z. R. Li, F. Zhu*, X. B. Sui*. NPCDR: natural product-based drug combination and its disease-specific molecular regulation. Nucleic Acids Research. 50(D1): 1324-1333 (2020). PMID: 34664659

Prof. Feng ZHU  (zhufeng@zju.edu.cn)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China


Prof. Xinbing SUI  (hzzju@hznu.edu.cn)

School of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China