Natural Product (NP) Details
| General Information of the NP (ID: NP8680) | |||||
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| Name |
Glycyrol
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| Synonyms |
Glycyrol; Neoglycyrol; 23013-84-5; CHEBI:80832; 3,9-dihydroxy-1-methoxy-2-(3-methylbut-2-enyl)-[1]benzofuro[3,2-c]chromen-6-one; MLS000697623; SCHEMBL758197; CHEMBL132695; DTXSID00177569; HMS2270J05; HY-N3961; ZINC13130921; AKOS032949068; SMR000470955; 3,9-Dihydroxy-1-methoxy-2-prenylcoumestan; CS-0024524; FT-0775552; C16968; Q27149874; 3,9-Dihydroxy-1-methoxy-2-(3-methyl-but-2-enyl)-benzofuro[3,2-c][1]benzopyran-6-one; 3,9-dihydroxy-1-methoxy-2-(3-methylbut-2-enyl)benzofuro[3,2-c]chromen-6-one; 6H-Benzofuro(3,2-c)(1)benzopyran-6-one, 3,9-dihydroxy-1-methoxy-2-(3-methyl-2-butenyl)-; 3,9-dihydroxy-1-methoxy-2-(3-methylbut-2-en-1-yl)-6H-[1]benzofuro[3,2-c][1]benzopyran-6-one
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| Species Origin | Glycyrrhiza uralensis ... | Click to Show/Hide | |||
| Glycyrrhiza uralensis | |||||
| Disease | Rheumatoid arthritis [ICD-11: FA20] | Investigative | [1] | ||
| Structure |
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| Formula |
C21H18O6
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| PubChem CID | |||||
| Canonical SMILES |
CC(=CCC1=C(C2=C(C=C1O)OC(=O)C3=C2OC4=C3C=CC(=C4)O)OC)C
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| InChI |
1S/C21H18O6/c1-10(2)4-6-12-14(23)9-16-18(19(12)25-3)20-17(21(24)27-16)13-7-5-11(22)8-15(13)26-20/h4-5,7-9,22-23H,6H2,1-3H3
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| InChIKey |
LWESBHWAOZORCQ-UHFFFAOYSA-N
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| CAS Number |
CAS 23013-84-5
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| ChEBI ID | |||||
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| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Fluconazole | Fungal infection | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| In-vivo Model | Mouse was shaved with electric clippers and an approximately 4 cm2 area was marked and slightly abraded with sterile sandpaper before infection with 20 ul of suspension containing 1*106 C. albicans. | |||||
| Experimental
Result(s) |
It is very likely that, by damaging the cell wall, glycyrol helps fluconazole invade C. albicans more readily and attack fluconazole's target in the fungus membrane. | |||||
