Natural Product (NP) Details

General Information of the NP (ID: NP8848)
Name
Danthron
Synonyms
danthron; 1,8-Dihydroxyanthraquinone; 117-10-2; Chrysazin; Dantron; Antrapurol; Dorbane; Istizin; Laxanthreen; Diaquone; Laxanorm; Altan; 1,8-Dihydroxyanthracene-9,10-dione; Laxipurin; Zwitsalax; Danivac; Dionone; Duolax; Laxipur; 9,10-Anthracenedione, 1,8-dihydroxy-; danthrone; Modane; Prugol; Roydan; 1,8-Dihydroxy-9,10-anthraquinone; 1,8-Dihydroxyanthrachinon; Usaf nd-59; Dioxyanthrachinonum; Chrysazine; Dantrone; Dorbanex; 1,8-Dihydroxyanthra-9,10-quinone; 1,8-Dihydroxy-9,10-anthracenedione; Criasazin; Dantrona; Dantronum; LTAN; Anthraquinone, 1,8-dihydroxy-; 1,8-Dihydroanthraquinone; UNII-Z4XE6IBF3V; 1,8-dihydroxy-anthraquinone; MFCD00001211; NSC 38626; NSC 646568; NSC7210; Z4XE6IBF3V; CHEMBL53418; CHEBI:3682; Pastomin; Bancon; Istan; component of Doxan; Neokutin S; component of Modane; Scatron D; 1,8-dihydroxy-9,10-dihydroanthracene-9,10-dione; Dantron (INN); Dantron [INN]; component of Doxidan; NSC646568; component of Dorbantyl; NCGC00091367-01; NCGC00091367-05; 9, 1,8-dihydroxy-; DSSTox_CID_328; Anthraquinone,8-dihydroxy-; Dantrone [INN-French]; Dantronum [INN-Latin]; Dantrona [INN-Spanish]; DSSTox_RID_75516; DSSTox_GSID_20328; 1,4,5,8-Tetroxyantraquinone; 1,8-Dihydroxyanthraquinone, 95%; WLN: L C666 BV IVJ DQ NQ; 1,8-Dihydroxyanthrachinon [Czech]; Danthron [USP]; CAS-117-10-2; CCRIS 3529; EINECS 204-173-5; Istizine; Laxapur; AI3-38117; HSDB 7764; 3nsq; Danthron, BAN; Dantron, INN; ACMC-20mzuc; Dorbanex (Salt/Mix); Dorbantyl (Salt/Mix); 1,10-Anthracenedione, 8,9-dihydroxy-; Spectrum_001750; dihyanthraquin_P41_LT; Spectrum2_000603; Spectrum3_000650; Spectrum4_001682; Spectrum5_000324; dihyanthraquin_P21/n_LT; NCIMech_000114; dihyanthraquin_P41212_RT; 1,8 Dihydroxy Anthraquinone; SCHEMBL83688; Anthraquinone-related compound; BSPBio_002259; KBioGR_001944; KBioSS_002230; SPECTRUM211468; MLS000069608; Pilules Vinchy N.F. (TN); ARONIS23892; DivK1c_000284; SPBio_000506; MEGxp0_001693; DTXSID9020328; ACon1_000135; BDBM11316; HMS500O06; KBio1_000284; KBio2_002230; KBio2_004798; KBio2_007366; KBio3_001479; 1,8-Dihydroxyanthraquinone ,(S); 1,8-Dihydroxyanthraquinone-[d6]; dihyanthraquin_P41_LT-Polymorph5; dihyanthraquin_P41_RT-Polymorph1; NINDS_000284; 1,8-Dihydroxyanthraquinone, 96%; HMS2091A09; HMS3715F08; Pharmakon1600-00211468; 8,9-dihydroxy-1,10-anthraquinone; BCP31079; HY-B0923; NSC-7210; NSC38626; ZINC3860369; Tox21_111122; Tox21_200986; ANW-17004; BBL013161; CCG-35470; NSC-38626; NSC755828; s4561; SBB057973; STK238373; AKOS001583216; Tox21_111122_1; 1,8-Dihydroxyanthra-9,10-quinone #; AM10629; CS-4392; DB04816; HS-1003; MCULE-5800615690; NSC-646568; NSC-755828; IDI1_000284; NCGC00091367-02; NCGC00091367-03; NCGC00091367-04; NCGC00091367-06; NCGC00091367-07; NCGC00258539-01; 1,8-bis(oxidanyl)anthracene-9,10-dione; 140861-59-2; AK208660; NCI60_041443; R229; SMR000059018; SY011288; SBI-0051330.P003; 1,8-Dihydroxy-9,10-anthracenedione, 9CI; D0563; EU-0099935; FT-0624445; ST50330603; C10312; D07107; 1,8-Dihydroxyanthracene-9,10-dione (Danthron); AB00051961_09; Danthron (1,8-Dihydroxyanthracene-9,10-dione); A803710; SR-01000721864; Q5221244; SR-01000721864-2; W-108572; BRD-K10065684-001-02-5; BRD-K10065684-001-03-3; BRD-K10065684-001-06-6; 1,8-Dihydroxyanthraquinone, Vetec(TM) reagent grade, 96%; Dantron; Chrysazin;1,8-Dihydroxyanthraquinone;1,4,5,8-tetroxyantraquinone
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Species Origin Rheum palmatum ...     Click to Show/Hide
Rheum palmatum
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Caryophyllales
Family: Polygonaceae
Genus: Rheum
Species: Rheum palmatum
Disease Joint derangement [ICD-11: FA34] Withdrawn from market [1]
Structure
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2D MOL

3D MOL

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Formula
C14H8O4
PubChem CID
2950
Canonical SMILES
C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=CC=C3O
InChI
1S/C14H8O4/c15-9-5-1-3-7-11(9)14(18)12-8(13(7)17)4-2-6-10(12)16/h1-6,15-16H
InChIKey
QBPFLULOKWLNNW-UHFFFAOYSA-N
CAS Number
CAS 117-10-2
ChEBI ID
CHEBI:3682
Herb ID
HBIN022668
TTD Drug ID
D0J0EL
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Doxorubicin      Solid tumour/cancer     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Experimental
                    Result(s)		 Danthron has an anticancer effect and can sensitize the chemotherapeutic effect of doxorubicin on pancreatic cancer cells.
References
Reference 1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Reference 2 Danthron suppresses autophagy and sensitizes pancreatic cancer cells to doxorubicin. Toxicol In Vitro. 2019 Feb;54:345-353.
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