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Natural Product (NP) Details

General Information of the NP (ID: NP9338)
Name
Manuka honey
Species Origin Apis mellifera ...     Click to Show/Hide
Apis mellifera
Kingdom: Metazoa
Phylum: Arthropoda
Class: Insecta
Order: Hymenoptera
Family: Apidae
Genus: Apis
Species: Apis mellifera
Disease Sinusitis [ICD-11: CA0A] Phase 2 [1]
Herb ID
HBIN034310
SymMap ID
SMIT02214
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Salazosulfapyridine      Rheumatoid arthritis     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model In vivo experiment was carried out with rats.
                    Experimental
                    Result(s)
Combination therapy showed additive effect of the MH which restored lipid peroxidation and improvement of antioxidant parameters.
References
Reference 1 ClinicalTrials.gov (NCT01350193) Manuka Honey Irrigation After Sinus Surgery
Reference 2 Effect of Manuka honey and sulfasalazine in combination to promote antioxidant defense system in experimentally induced ulcerative colitis model in rats. Indian J Exp Biol. 2008 Aug;46(8):583-90.
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Cite NPCDR
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Correspondence

X. N. Sun, Y. T. Zhang, Y. Zhou, X. C. Lian, L. L. Yan, T. Pan, T. Jin, H. Xie, Z. M. Liang, W. Q. Qiu, J. X. Wang, Z. R. Li, F. Zhu*, X. B. Sui*. NPCDR: natural product-based drug combination and its disease-specific molecular regulation. Nucleic Acids Research. 50(D1): 1324-1333 (2020). PMID: 34664659

Prof. Feng ZHU  (zhufeng@zju.edu.cn)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China


Prof. Xinbing SUI  (hzzju@hznu.edu.cn)

School of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China