Molecule Details

Natural Product(s) of This Target
1 Roxithromycin  NP Info  Withdrawn from market Escherichia coli
Drug(s) of This Target
1 Clarithromycin  Drug Info  Approved Bacterial infection
2 Clindamycin  Drug Info  Approved Acne vulgaris
3 CPT-11  Drug Info  . Not Available
4 Erythromycin  Drug Info  Approved Bacterial infection
5 Lincomycin  Drug Info  Approved Gram-positive bacterial infection
References
Reference 1 Molecular insights into 14-membered macrolides using the MM-PBSA method. J Chem Inf Model. 2009 Jun;49(6):1558-67.
Reference 2 Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21.
Reference 3 A synthetic alanyl-initiator tRNA with initiator tRNA properties as determined by fluorescence measurements: comparison to a synthetic alanyl-elongator tRNA. Nucleic Acids Res. 1991 Oct 25;19(20):5749-54.
Reference 4 Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide, and streptogramin B antibiotics. Curr Microbiol. 2000 Aug;41(2):126-35.