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Molecule Details
General Information of the Molecule
Name
Sphingolipid delta(4)-desaturase DES1 (DEGS1)
Synonyms
Cell migration-inducing gene 15 protein; Degenerative spermatocyte homolog 1; Dihydroceramide desaturase-1; Membrane lipid desaturase
Gene Name
DEGS1
Gene ID
8560
Sequence
MGSRVSREDFEWVYTDQPHADRRREILAKYPEIKSLMKPDPNLIWIIIMMVLTQLGAFYI
VKDLDWKWVIFGAYAFGSCINHSMTLAIHEIAHNAAFGNCKAMWNRWFGMFANLPIGIPY
SISFKRYHMDHHRYLGADGVDVDIPTDFEGWFFCTAFRKFIWVILQPLFYAFRPLFINPK
PITYLEVINTVAQVTFDILIYYFLGIKSLVYMLAASLLGLGLHPISGHFIAEHYMFLKGH
ETYSYYGPLNLLTFNVGYHNEHHDFPNIPGKSLPLVRKIAAEYYDNLPHYNSWIKVLYDF
VMDDTISPYSRMKRHQKGEMVLE
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Function
Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) . Catalyzes the equilibrium isomerization of retinols
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Uniprot ID
DEGS1_HUMAN
EC Number
EC: 1.14.19.17
Pfam
PF00487
; PF08557
KEGG ID
hsa8560
Drug(s) of This Target
1
SMC3
Drug Info
Investigative
Breast cancer
References
Reference 1
N-(4-Hydroxyphenyl) Retinamide Suppresses SARS-CoV-2 Spike Protein-Mediated Cell-Cell Fusion by a Dihydroceramide delta4-Desaturase 1-Independent Mechanism. J Virol. 2021 Aug 10;95(17):e0080721.
