Molecule Details
| General Information of the Molecule | ||||
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| Name |
Plasmodium dihydroorotase (Malaria dho)
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| Synonyms |
Dihydroorotase
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| Gene Name |
Malaria dho
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| Sequence |
MKNYFYIPIADDMHCHLRQGDMLDFTVNSIRRGGCNRVLVMPNTHPIISTCSDAQKYLYQ
LKSRDDDIEYLMTLYLNKNTDENDILSNYYKCNLQGVKIYPSNVTTNSSDGITSLEPYYK VFHALEKLNKSIHIHCEEPNINPLYAEEKYLPHIHDLAIKFPGLNIVLEHISSSESINVI KEFRNVAGSITPHHLYLTIDDVVNMDIYDHAIDNTYIEKYIKNTYHYCKPLPKLLEDKIA LQDVIKDDFPRVFLGSDSAPHYKVMKRKPYYKPGIYTQPFLINYVAHILNKFDALDKMEN FTSKNASLFLNLAEKKKLAKYYICVEKHPFKLPREYNGVVPFLAGKTLDYDIHYVSKF Click to Show/Hide
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| Function |
A Zn2+ amidohydrolase superfamily that catalyzes reversible cyclization of N-carbamoyl-L-aspartate (L-CA) to form L-dihydroorotate (L-DHO).
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| Uniprot ID | ||||
| TTD ID | ||||
| Natural Product(s) of This Target | ||||
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| 1 | Fluoroorotic acid | NP Info | Investigative | Homo sapiens |
| References | ||||
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| Reference 1 | Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301. | |||