Molecule Details

General Information of the Molecule

Name

Lactoylglutathione lyase (GLO1)

Synonyms

S-D-lactoylglutathione methylglyoxal lyase; Methylglyoxalase; Ketone-aldehyde mutase; Glyoxalase I; GlxI; Glx I; GLO1; Aldoketomutase

Gene Name

GLO1

Gene ID

2739

Sequence

MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQK
CDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNS
DPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKM
ATLM

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Function

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis.

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Uniprot ID

LGUL_HUMAN

EC Number

EC: 4.4.1.5

TC Number

TC: 4.4.1.5

Pfam

PF00903

TTD ID

T88285

Natural Product(s) of This Target

Kaempferol

NP Info

Investigative

Equisetum hyemale

Naringenin

NP Info

Phase 1

Potentilla discolor

References

Reference 1

Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects. Bioorg Med Chem. 2008 Apr 1;16(7):3969-75.

Molecule Details

Cite NPCDR

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Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xinbing SUI (suilab@hznu.edu.cn)