Molecule Details
| General Information of the Molecule | ||||
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| Name |
Prostaglandin transporter (SLC21A2)
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| Synonyms |
Solute carrier organic anion transporter family member 2A1; Solute carrier family 21 member 2; PGT; OATP2A1
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| Gene Name |
SLCO2A1
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| Gene ID | ||||
| Sequence |
MGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIE
KRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHF LSEPYQYTLASTGNNSRLQAELCQKHWQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLA GIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVN TAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLE EAKSRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTS AAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGC STPTVAEVYPPSTSSSIHPQSPACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMS SATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLPAIFLISFVSLIACISHNPLYMMV LRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDND ALRDRYLGLQMGYKALGMLLLCFISWRVKKNKEYNVQKAAGLI Click to Show/Hide
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| Function |
Transports PGD2, as well as PGE1, PGE2 and PGF2A. May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation.
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| Uniprot ID | ||||
| Pfam | ||||
| TTD ID | ||||
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| Drug(s) of This Target | ||||
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| 1 | Bacillus Calmette-Guerin | Drug Info | Phase 3 | Bladder cancer |
| References | ||||
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| Reference 1 | Identification and characterization of a prostaglandin transporter. Science. 1995 May 12;268(5212):866-9. | |||