Molecule Details

General Information of the Molecule

Name

Cathepsin B (CTSB)

Synonyms

Ctsb; Cathepsins B; Cathepsin-B; Cathepsin B1; CPSB; APPS; APP secretase

Gene Name

CTSB

Gene ID

1508

Sequence

MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI

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Function

Cleaves matrix extracellular phosphoglycoprotein MEPE. Has also been implicated in tumor invasion and metastasis. Thiol protease which is believed to participate in intracellular degradation and turnover of proteins.

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Uniprot ID

CATB_HUMAN

EC Number

EC: 3.4.22.1

Pfam

PF00112 ; PF08127

KEGG ID

hsa1508

TTD ID

T61746

Natural Product(s) of This Target

Cepharanthine

NP Info

Investigative

Stephania delavayi

References

Reference 1

Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell?lung cancer. Cancer Lett. 2018 Jan 1;412:1-9.

Molecule Details

Cite NPCDR

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Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xinbing SUI (hzzju@hznu.edu.cn)