Molecule Details
| General Information of the Molecule | ||||
|---|---|---|---|---|
| Name |
V-set and transmembrane domain-containing 1 (VSTM1)
|
|||
| Synonyms |
Signal inhibitory receptor on leukocytes-1; SIRL-1
|
|||
| Gene Name |
VSTM1
|
|||
| Gene ID | ||||
| Sequence |
MTAEFLSLLCLGLCLGYEDEKKNEKPPKPSLHAWPSSVVEAESNVTLKCQAHSQNVTFVL
RKVNDSGYKQEQSSAENEAEFPFTDLKPKDAGRYFCAYKTTASHEWSESSEHLQLVVTDK HDELEAPSMKTDTRTIFVAIFSCISILLLFLSVFIIYRCSQHSSSSEESTKRTSHSKLPE QEAAEADLSNMERVSLSTADPQGVTYAELSTSALSEAASDTTQEPPGSHEYAALKV Click to Show/Hide
|
|||
| Function |
Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17).
Click to Show/Hide
|
|||
| Uniprot ID | ||||
| Pfam | ||||
| KEGG ID | ||||
| Drug(s) of This Target | ||||
|---|---|---|---|---|
| 1 | Octyl disulfamate | Drug Info | Investigative | Breast cancer |
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic antitumor activity of triple-regulated oncolytic adenovirus with VSTM1 and daunorubicin in leukemic cells. Apoptosis. 2016 Oct;21(10):1179-90. | |||