Molecule Details
| General Information of the Molecule | ||||
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| Name |
Interleukin 2 receptor alpha (IL2RA)
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| Synonyms |
TAC antigen; Interleukin-2 receptor subunit alpha; IL2-RA; IL-2R subunit alpha; IL-2-RA; IL-2 receptor subunit alpha; IL-2 receptor alpha subunit; CD25 antigen; CD25
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| Gene Name |
IL2RA
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| Gene ID | ||||
| Sequence |
MDSYLLMWGLLTFIMVPGCQAELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKS
GSLYMLCTGNSSHSSWDNQCQCTSSATRNTTKQVTPQPEEQKERKTTEMQSPMQPVDQAS LPGHCREPPPWENEATERIYHFVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQP QLICTGEMETSQFPGEEKPQASPEGRPESETSCLVTTTDFQIQTEMAATMETSIFTTEYQ VAVAGCVFLLISVLLLSGLTWQRRQRKSRRTI Click to Show/Hide
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| Function |
The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. Receptor for interleukin-2.
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| Uniprot ID | ||||
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| Drug(s) of This Target | ||||
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| 1 | hu14.18-IL2 immunicytokine | Drug Info | Phase 2 | Melanoma |
| 2 | SLC-0111 | Drug Info | Phase 1 | Solid tumour/cancer |