Molecule Details

General Information of the Molecule

Name

Thymidine kinase 2 (TK2)

Synonyms

dnk; Multispecific deoxynucleoside kinase; Mt-TK2; Dm-Dnk; Deoxyribonucleoside kinase

Gene Name

TK2

Gene ID

7084

Sequence

MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIA
SGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDR
HTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIV
YLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHH
MERMLELFEQNRDRILTPENRKHCP

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Function

Deoxyribonucleoside kinase that has a broad specificity phosphorylating thymidine, deoxyadenosine, deoxycytidine and deoxyguanosine. Specificity is higher for pyrimidine nucleosides. Several anti-viral and anti-cancer nucleoside analogs are also efficiently phosphorylated.

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Uniprot ID

KITM_HUMAN

EC Number

EC: 2.7.1.21

Pfam

PF01712

KEGG ID

hsa7084

TTD ID

T22976

Drug(s) of This Target

Thymidine kinase/ganciclovir

Drug Info

Approved

Cytomegaloviral disease

References

Reference 1

Ganciclovir. Profiles Drug Subst Excip Relat Methodol. 2018;43:1-208.

Molecule Details

Cite NPCDR

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Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xinbing SUI (suilab@hznu.edu.cn)