Molecule Details
| General Information of the Molecule | ||||
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| Name |
C-C chemokine receptor type 3 (CCR3)
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| Synonyms |
Eosinophil eotaxin receptor; Chemokine receptor CCR3; CMKBR3; CKR3; CD193; CCR-3; CC-CKR-3; C-C CKR-3
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| Gene Name |
CCR3
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| Gene ID | ||||
| Sequence |
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILI
KYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSE IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEE TLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRL IFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVI YAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF Click to Show/Hide
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| Function |
Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Receptor for a C-C type chemokine.
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| Uniprot ID | ||||
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| KEGG ID | ||||
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| Drug(s) of This Target | ||||
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| 1 | Proanthocyanidins | Drug Info | Phase 2 | Atherosclerosis |
| References | ||||
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| Reference 1 | Proanthocyanidins: A comprehensive review. Biomed Pharmacother. 2019 Aug;116:108999. | |||