Molecule Details

General Information of the Molecule

Name

Bacterial Fatty acid synthetase I (Bact inhA)

Synonyms

Enoyl-[acyl-carrier-protein] reductase [NADH]; Bacterial InhA

Gene Name

Bact inhA

Gene ID

45425463;886523

Sequence

MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPL
LELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGI
HISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAG
KYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAK
TVCALLSDWLPATTGDIIYADGGAHTQLL

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Function

Involved in the resistance against the antituberculosis drugs isoniazid and ethionamide.

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Uniprot ID

INHA_MYCTU

EC Number

EC: 1.3.1.118 ; EC: 1.3.1.9

TTD ID

T79068

Drug(s) of This Target

Ethionamide

Drug Info

Approved

HIV-infected patients with tuberculosis

Isoniazid

Drug Info

Approved

HIV-infected patients with tuberculosis

References

Reference 1

Mechanism of thioamide drug action against tuberculosis and leprosy. J Exp Med. 2007 Jan 22;204(1):73-8.

Reference 2

Diversity in enoyl-acyl carrier protein reductases. Cell Mol Life Sci. 2009 May;66(9):1507-17.

Molecule Details

Cite NPCDR

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Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xinbing SUI (suilab@hznu.edu.cn)