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Molecule Details

General Information of the Molecule
Name
Poly [ADP-ribose] polymerase (PARP)
Synonyms
Poly-ADP-ribose polymerase
Uniprot ID
NOUNIPROTAC
TTD ID
T34867
Natural Product(s) of This Target
1 Alantolactone  NP Info  Inula helenium
2 Aronia berry extract  NP Info  . Not Available
3 Paeoniae radix  NP Info  Paeonia lactiflora
Drug(s) of This Target
1 ABT-888  Drug Info  Phase 3 Malignant mesenchymal neoplasm
2 Olaparib  Drug Info  Approved Ovarian cancer
References
Reference 1 Down-Regulation of AKT Signalling by Ursolic Acid Induces Intrinsic Apoptosis and Sensitization to Doxorubicin in Soft Tissue Sarcoma. PLoS One. 2016 May 24;11(5):e0155946.
Reference 2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
Reference 3 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
Cite NPCDR
Visitor Map
Correspondence

X. N. Sun, Y. T. Zhang, Y. Zhou, X. C. Lian, L. L. Yan, T. Pan, T. Jin, H. Xie, Z. M. Liang, W. Q. Qiu, J. X. Wang, Z. R. Li, F. Zhu*, X. B. Sui*. NPCDR: natural product-based drug combination and its disease-specific molecular regulation. Nucleic Acids Research. 50(D1): 1324-1333 (2020). PMID: 34664659

Prof. Feng ZHU  (zhufeng@zju.edu.cn)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China


Prof. Xinbing SUI  (suilab@hznu.edu.cn)

School of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China