Molecule Details

General Information of the Molecule

Name

Thymidine kinase 1 (TK1)

Synonyms

Thymidine kinase, cytosolic

Gene Name

TK1

Gene ID

7083

Sequence

MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTR
YSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVI
VAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADK
YHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN

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Function

cytosol, identical protein binding, thymidine kinase activity, zinc ion binding, DNA metabolic process, nucleobase-containing compound metabolic process, protein homotetramerization, pyrimidine nucleoside salvage, thymidine metabolic process

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Uniprot ID

KITH_HUMAN

EC Number

EC: 2.7.1.21

Pfam

PF00265

TTD ID

T30081

Natural Product(s) of This Target

Penciclovir

NP Info

Approved

Homo sapiens

Drug(s) of This Target

HSV-TK/GCV

Drug Info

Phase 2

Ovarian cancer

Thymidine kinase/ganciclovir

Drug Info

Approved

Cytomegaloviral disease

References

Reference 1

How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

Reference 2

Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.

Reference 3

Ganciclovir. Profiles Drug Subst Excip Relat Methodol. 2018;43:1-208.

Molecule Details

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Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xinbing SUI (hzzju@hznu.edu.cn)