Molecule Details
| General Information of the Molecule | ||||
|---|---|---|---|---|
| Name |
Adrenergic receptor beta-2 (ADRB2)
|
|||
| Synonyms |
Beta-2 adrenoreceptor; Beta-2 adrenoceptor; Beta-2 adrenergic receptor; B2AR; ADRB2R
|
|||
| Gene Name |
ADRB2
|
|||
| Gene ID | ||||
| Sequence |
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL Click to Show/Hide
|
|||
| Function |
The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins.
Click to Show/Hide
|
|||
| Uniprot ID | ||||
| TC Number | ||||
| Pfam | ||||
| TTD ID | ||||
| Drug(s) of This Target | ||||
|---|---|---|---|---|
| 1 | Salmeterol | Drug Info | Approved | Chronic obstructive pulmonary disease |
| References | ||||
|---|---|---|---|---|
| Reference 1 | Pharmacogenetic tests in asthma therapy. Clin Lab Med. 2008 Dec;28(4):645-65. | |||