Molecule Details

General Information of the Molecule

Name

Vitamin K epoxide reductase complex 1 (VKORC1)

Synonyms

Vitamin K1 2,3-epoxide reductase subunit 1; VKORC1; VKOR; UNQ308/PRO351; MSTP576; MSTP134

Gene Name

VKORC1

Gene ID

79001

Sequence

MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWG
RGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYL
AWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH

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Function

Involved invitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.

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Uniprot ID

VKOR1_HUMAN

EC Number

EC: 1.17.4.4

Pfam

PF07884

TTD ID

T11843

Natural Product(s) of This Target

Coumarins

NP Info

Approved

Vanilla fragrans

Dicoumarol

NP Info

Approved

Vanilla fragrans

References

Reference 1

[Oral anticoagulation and pharmacogenetics: importance in the clinical setting]. Rev Med Suisse. 2007 Sep 12;3(124):2030, 2033-4, 2036.

Reference 2

Vitamin K antagonism of coumarin intoxication in the rat. Thromb Haemost. 1986 Apr 30;55(2):235-9.

Molecule Details

Cite NPCDR

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Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xinbing SUI (suilab@hznu.edu.cn)