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Manual
Molecule Details
General Information of the Molecule
Name
Bacterial Enterobacter Beta-lactamase (Bact ampC)
Synonyms
Cephalosporinase
Gene Name
ampC
Sequence
MMRKSLCCALLLGISCSALATPVSEKQLAEVVANTITPLMKAQSVPGMAVAVIYQGKPHY
YTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDAVTRYWPQLTGKQ
WQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGA
LAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQA
YGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEA
NTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLA
NTSYPNPARVEAAYHILEALQ
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Function
This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
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Uniprot ID
AMPC_ENTCL
EC Number
EC: 3.5.2.6
Pfam
PF00144
Drug(s) of This Target
1
SG611-VSTM1
Drug Info
Investigative
Acute lymphoblastic leukemia
References
Reference 1
In vitro activity of avibactam (NXL104) in combination with Beta-lactams against Gram-negative bacteria, including OXA-48 Beta-lactamase-producing Klebsiella pneumoniae. Int J Antimicrob Agents. 2012 Jan;39(1):86-9.
