Molecule Details

General Information of the Molecule

Name

Matrix metalloproteinase-9 (MMP-9)

Synonyms

Matrix metalloproteinase 9; GELB; CLG4B; 92 kDa type IV collagenase; 92 kDa gelatinase

Gene Name

MMP9

Gene ID

GeneID:4318

Sequence

MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEM
RGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHN
ITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYP

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Function

Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration.

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Uniprot ID

MMP9_HUMAN

EC Number

EC: 3.4.24.35

KEGG ID

hsa:4318

TTD ID

T54156

Natural Product(s) of This Target

Chuanxiong Rhizoma

NP Info

Not Available

Drug(s) of This Target

Temozolomide

Drug Info

Approved

Brain cancer

Molecule Details

Cite NPCDR

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Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xinbing SUI (suilab@hznu.edu.cn)