Molecule Details

General Information of the Molecule

Name

Glutathione reductase (GR)

Synonyms

Glutathione reductase, mitochondrial; GRase; GRD1; GLUR

Gene Name

GSR

Gene ID

2936

Sequence

MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK
TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD
EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR

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Function

Maintains high levels of reduced glutathione in the cytosol.

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Uniprot ID

GSHR_HUMAN

EC Number

EC: 1.8.1.7

Pfam

PF07992 ; PF02852

KEGG ID

hsa2936

TTD ID

T30803

INTEDE ID

DME0110

Drug(s) of This Target

Lcotinib

Drug Info

Investigative

Pulmonary hypertension

References

Reference 1

Effect of inhibition of glutathione reductase by carmustine on central nervous system oxygen toxicity. J Pharmacol Exp Ther. 1987 Jan;240(1):111-7.

Molecule Details

Cite NPCDR

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Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xinbing SUI (hzzju@hznu.edu.cn)