Molecule Details

General Information of the Molecule

Name

FK506-binding protein 1A (FKBP1A)

Synonyms

Rotamase; Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; Immunophillin FKBP; Immunophilin FKBP12; FKBP12; FKBP1; FKBP-1A; FKBP-12; FK-binding protein 12; Calstabin-1; 12 kDa FKBP; 12 kDa FK506-binding protein

Gene Name

FKBP1A

Gene ID

2280

Sequence

MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE

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Function

Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand.

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Uniprot ID

FKB1A_HUMAN

EC Number

EC: 5.2.1.8

TC Number

TC: 5.2.1.8

Pfam

PF00254

TTD ID

T76059

Drug(s) of This Target

Rapamycin

Drug Info

Approved

Multiple myeloma

References

Reference 1

Neural roles of immunophilins and their ligands. Mol Neurobiol. 1997 Oct;15(2):223-39.

Molecule Details

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Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xinbing SUI (hzzju@hznu.edu.cn)