Molecule Details

General Information of the Molecule

Name

Phospholipase A2 (PLA2G1B)

Synonyms

Secreted phospholipase A(2); Phosphatidylcholine 2-acylhydrolase 1B; PLA2G1B; Group IB phospholipase A2

Gene Name

PLA2G1B

Gene ID

5319

Sequence

MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPV
DELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNC
DRNAAICFSKAPYNKAHKNLDTKKYCQS

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Function

PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.

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Uniprot ID

PA21B_HUMAN

EC Number

EC: 3.1.1.4

TC Number

TC: 3.1.1.4

Pfam

PF00068

TTD ID

T31479

Natural Product(s) of This Target

Methylglyoxal

NP Info

Investigative

Saccharomyces cerevisiae

Miltefosine

NP Info

Approved

Coconut leaflet phytoplasma

Ursolic acid

NP Info

Investigative

Potentilla indica

References

Reference 1

How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

Reference 2

Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol. 2009 Mar 31;26(1):15-22.

Reference 3

Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4100-4.

Molecule Details

Cite NPCDR

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Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xinbing SUI (suilab@hznu.edu.cn)