Molecule Details
| General Information of the Molecule | ||||
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| Name |
COPII-associated small GTPase (SAR1A)
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| Synonyms |
Activator of 90 kDa heat shock protein ATPase homolog 1
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| Gene Name |
SAR1A
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| Gene ID | ||||
| Sequence |
MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPT
SEELTIAGMTFTTFDLGGHEQARRVWKNYLPAINGIVFLVDCADHSRLVESKVELNALMT DETISNVPILILGNKIDRTDAISEEKLREIFGLYGQTTGKGNVTLKELNARPMEVFMCSV LKRQGYGEGFRWLSQYID Click to Show/Hide
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| Function |
Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).
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| Uniprot ID | ||||
| Pfam | ||||
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| Natural Product(s) of This Target | ||||
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| 1 | Hypericin | NP Info | Phase 1 | Hypericum perforatum |
| References | ||||
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| Reference 1 | Hypericin enhances Beta-lactam antibiotics activity by inhibiting sarA expression in methicillin-resistant Staphylococcus aureus. Acta Pharm Sin B. 2019 Nov;9(6):1174-1182. | |||