Molecule Details
General Information of the Molecule | ||||
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Name |
WD repeat-containing protein 7 (BATF2)
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Synonyms |
B-ATF-2; Suppressor of AP-1 regulated by IFN; SARI
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Gene Name |
BATF2
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Gene ID | ||||
Sequence |
MHLCGGNGLLTQTDPKEQQRQLKKQKNRAAAQRSRQKHTDKADALHQQHESLEKDNLALR
KEIQSLQAELAWWSRTLHVHERLCPMDCASCSAPGLLGCWDQAEGLLGPGPQGQHGCREQ LELFQTPGSCYPAQPLSPGPQPHDSPSLLQCPLPSLSLGPAVVAEPPVQLSPSPLLFASH TGSSLQGSSSKLSALQPSLTAQTAPPQPLELEHPTRGKLGSSPDNPSSALGLARLQSREH KPALSAATWQGLVVDPSPHPLLAFPLLSSAQVHF Click to Show/Hide
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Function |
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter.
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Uniprot ID | ||||
Pfam | ||||
KEGG ID |
Natural Product(s) of This Target | ||||
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1 | Calycosin | NP Info | Investigative | Astragalus |