Drug Combination Details
| General Information of the Combination (ID: C00042) | |||||
|---|---|---|---|---|---|
| Name | Metformin NP Info | + | Nelfinavir Drug Info | ||
| Structure |
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+ |
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| Disease |
Cervical cancer
[ICD-11: 2C77]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CDKN1A | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | PIK3CB | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
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| In-vitro Model | HeLa | CVCL_0030 | Endocervical adenocarcinoma | Homo sapiens | ||
| SiHa | CVCL_0032 | Cervical squamous cell carcinoma | Homo sapiens | |||
| Ca Ski | CVCL_1100 | Cervical squamous cell carcinoma | Homo sapiens | |||
| In-vivo Model | Cervical cancer cell xenograft in vivo in nude mice were used in this study. | |||||
| Experimental
Result(s) |
Combining metformin and nelfinavir exhibits synergistic effects against the growth of human cervical cancer cells and xenograft in nude mice. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Combining metformin and nelfinavir exhibits synergistic effects against the growth of human cervical cancer cells and xenograft in nude mice. Sci Rep. 2017 Mar 2;7:43373. | |||
