Drug Combination Details
| General Information of the Combination (ID: C00057) | |||||
|---|---|---|---|---|---|
| Name | Epigallocatechin gallate NP Info | + | Bicalutamide Drug Info | ||
| Structure |
|
+ |
|
||
| Disease |
Prostate cancer
[ICD-11: 2C82]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | SOD Mn | Molecule Info |
Pathway MAP
|
|
| Biological
Regulation |
Up-regulation | Apoptosis | ||||
| In-vitro Model | NRP-152 | CVCL_4869 | Healthy | Rattus norvegicus | ||
| NRP-154 | CVCL_4870 | Healthy | Rattus norvegicus | |||
| Experimental
Result(s) |
Epigallocatechin-3-gallate and bicalutamide cause growth arrest and apoptosis in NRP-152 and NRP-154 prostate epithelial cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Epigallocatechin-3-gallate and bicalutamide cause growth arrest and apoptosis in NRP-152 and NRP-154 prostate epithelial cells. Int J Urol. 2007 Jun;14(6):545-51. | |||
