Drug Combination Details
| General Information of the Combination (ID: C01797) | |||||
|---|---|---|---|---|---|
| Name | Curcumin NP Info | + | PD98059 Drug Info | ||
| Structure |
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+ |
|
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| Disease |
Stomach cancer
[ICD-11: 2B72]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
|
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| Up-regulation | Expression | microRNA 21 | Molecule Info |
Pathway MAP
|
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| Up-regulation | Expression | PTEN | Molecule Info |
Pathway MAP
|
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| In-vitro Model | MGC-803 | CVCL_5334 | Gastric mucinous adenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells. | |||||
