Drug Combination Details
| General Information of the Combination (ID: C01817) | |||||
|---|---|---|---|---|---|
| Name | Plaunotol NP Info | + | Clarithromycin Drug Info | ||
| Structure |
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+ |
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| Disease |
Gastric ulcer
[ICD-11: DA60]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| In-vivo Model | Specific-pathogen-free, 5-week-old male Mongolian gerbils were orally inoculated with 2 mL of bacterial suspension having a density of 1 * 108 cfu/mL. | |||||
| Experimental
Result(s) |
Plaunotol and clarithromycin combination exhibited synergistic effects in the treatment of diseases associated with clarithromycin-resistant H. pylori. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Effect of plaunotol in combination with clarithromycin against clarithromycin-resistant Helicobacter pylori in vitro and in vivo. J Antimicrob Chemother. 2007 Nov;60(5):1060-3. | |||
