Natural Product (NP) Details

General Information of the NP (ID: NP7288)
Name
Plaunotol
Synonyms
plaunotol; Kelnac; 64218-02-6; Plaunotolum; CS-684; 18-hydroxygeranylgeraniol; (E,Z,E)-7-Hydroxymethyl-3,11,15-trimethyl-2,6,10,14-hexadecatetraen-1-ol; UNII-MV715X4634; CHEBI:32023; MV715X4634; (2Z,6E)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-6-methylocta-2,6-diene-1,8-diol; (2Z,6E)-2-[(3E)-4,8-dimethylnona-3,7-dienyl]-6-methylocta-2,6-diene-1,8-diol; Plaunotolum [Latin]; Plaunotol [INN:JAN]; Kelnac (TN); (2Z,6E)-2-((E)-4,8-Dimethylnona-3,7-dien-1-yl)-6-methylocta-2,6-diene-1,8-diol; Plaunotol (JAN/INN); SCHEMBL440334; CHEMBL285815; 2,6-Octadiene-1,8-diol, 2-[(3e)-4,8-dimethyl-3,7-nonadienyl]-6-methyl-, (2Z,6E)-; ZINC13907151; LMPR0104010010; (2Z,6E)-2-((3E)-4,8-Dimethyl-3,7-nonadienyl)-6-methyl-2,6-octadiene-1,8-diol; 2,6,10,14-HEXADECATETRAEN-1-OL, 7-(HYDROXYMETHYL)-3,11,15-TRIMETHYL-, (E,Z,E)-; C13273; D01803; Q27114751; 2,6-Octadiene-1,8-diol, 2-(4,8-dimethyl-3,7-nonadienyl)-6-methyl-, (Z,E,E)- (9CI)
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Species Origin Croton sublyratus ...     Click to Show/Hide
Croton sublyratus
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Malpighiales
Family: Euphorbiaceae
Genus: Croton
Species: Croton sublyratus
Disease Ulcer [ICD-11: CA02-CB40] Approved [1]
Structure
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2D MOL

3D MOL

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Formula
C20H34O2
PubChem CID
5282197
Canonical SMILES
CC(=CCCC(=CCCC(=CCCC(=CCO)C)CO)C)C
InChI
1S/C20H34O2/c1-17(2)8-5-9-18(3)10-6-12-20(16-22)13-7-11-19(4)14-15-21/h8,10,13-14,21-22H,5-7,9,11-12,15-16H2,1-4H3/b18-10+,19-14+,20-13-
InChIKey
SUWYPNNPLSRNPS-UNTSEYQFSA-N
CAS Number
CAS 64218-02-6
ChEBI ID
CHEBI:32023
TTD Drug ID
D05XQE
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Clarithromycin      Bacterial infection     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vivo Model Specific-pathogen-free, 5-week-old male Mongolian gerbils were orally inoculated with 2 mL of bacterial suspension having a density of 1 * 108 cfu/mL.
                    Experimental
                    Result(s)		 Plaunotol and clarithromycin combination exhibited synergistic effects in the treatment of diseases associated with clarithromycin-resistant H. pylori.
References
Reference 1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Reference 2 Effect of plaunotol in combination with clarithromycin against clarithromycin-resistant Helicobacter pylori in vitro and in vivo. J Antimicrob Chemother. 2007 Nov;60(5):1060-3.
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