Drug Combination Details

General Information of the Combination (ID: C02976)
Name Cucurbitacin B   NP Info  + Gefitinib   Drug Info 
Structure +
Disease
Colorectal cancer [ICD-11: 2B91]
Investigative [1]
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. Enhancing Drug Efficacy by This Combination
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Experiment 1 Reporting the Effect of This Combination [1]
                    In-vitro Model HCT 116 CVCL_0291 Colon carcinoma Homo sapiens
HT-29 CVCL_0320 Colon adenocarcinoma Homo sapiens
                    Experimental
                    Result(s)		 CuB plus Gef treatment caused a significant growth and cell cycle inhibition and induced apoptosis in both cell lines.
References
Reference 1 Treatment with cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via EGFR and JAK/STAT pathway in human colorectal cancer cell lines. Hum Exp Toxicol. 2016 May;35(5):526-43.
 Download Picture         KEGG Link