Natural Product (NP) Details

General Information of the NP (ID: NP5888)
Name
Cucurbitacin B
Synonyms
Cucurbitacin B; 6199-67-3; Datisca principle B; Datiscn Principle B; 1,2-Dihydro-alpha-elaterin; UNII-0115W5MABF; 0115W5MABF; CHEBI:3941; CUCURBITACIN R - DATISCA PRINCIPLE B; NSC49451; Cucurbitacin-B; Cucurbitacin B hydrate; [(E,6R)-6-[(2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,7,8,10,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate; Cucurbitacine (B); Cucurbitacine B; (R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate; MLS002702988; HSDB 3476; 19-nor-9.beta.,23-diene-3,11,22-trione, 9-methyl-2.beta.,16.alpha.,20,25-tetrahydroxy-, 25-acetate; 19-Norlanosta-5,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2.beta.,9.beta.,10.alpha.,16.alpha.,23E)-; C32H46O8; NSC 49451; NSC 144154; cucurbitacin B derivatives; SCHEMBL231815; CHEMBL508185; HY-N0416; ZINC4097797; LMST01010104; MFCD07778083; NSC-49451; NSC144154; s8165; AKOS015897085; CCG-270043; CS-3816; NSC-144154; 25-(Acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione; 19-Nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione, 2beta,16alpha,20,25-tetrahydroxy-9-methyl-, 25-acetate; 19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2beta,9beta,10alpha,16alpha,23E)-; Cucurbitacin B hydrate, >=97% (HPLC); N2787; X1115; C08794; 199C673; Q-100715; Q27106259; UNII-W3RWP6CB48 component IXQKXEUSCPEQRD-DKRGWESNSA-N; (2S,4R,23E)-2,16beta,20-trihydroxy-9beta,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate; (3E,6R)-6-[(1R,2R,4S,10S,11S,13R,14R,15R)-4,13-dihydroxy-1,6,6,11,15-pentamethyl-5,17-dioxotetracyclo[8.7.0.0?,?.0??,??]heptadec-7-en-14-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate; 19-Nor-9-beta,10-alpha-lanosta-5,23-diene-3,11,22-trione, 2-beta,16-alpha,20,25-tetrahydroxy-9-methyl-, 25-acetate; 19-Norlanosta-5,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, [2.beta.,.gamma.,.beta.,10.alpha.,16.alpha.]-; 19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2beta,9beta,10alpha,16alpha,23E)- (9CI); 2beta,16alpha,20,25-tetrahydroxy-9-methyl-19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione, 25-acetate; 2beta,16alpha,20,25-tetrahydroxy-9-methyl-3,11,22-trioxo-19-nor-9beta,10alpha-lanosta-5,23-dien-25-yl acetate
    Click to Show/Hide
Species Origin Cucurbitaceae ...     Click to Show/Hide
Cucurbitaceae
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Cucurbitales
Family: Cucurbitaceae
Disease Stomach cancer [ICD-11: 2B72] Investigative [1]
Structure
Click to Download Mol
2D MOL

3D MOL

ADMET Property
Absporption
Caco-2 Permeability
 -5.103
 
MDCK Permeability
 -4.742
 
PAMPA
 +++
 
HIA
 - - -
 
Distribution
VDss
 0.13
 
PPB
 87.6%
 
BBB
 - - -
 
Metabolism
CYP1A2 inhibitor
 - - -
CYP1A2 substrate
 - - -
CYP2C19 inhibitor
 - - -
CYP2C19 substrate
 - - -
CYP2C9 inhibitor
 - - -
CYP2C9 substrate
 - - -
CYP2D6 inhibitor
 - - -
CYP2D6 substrate
 - - -
CYP3A4 inhibitor
 +
CYP3A4 substrate
 - - -
CYP2B6 inhibitor
 +++
CYP2B6 substrate
 - - -
CYP2C8 inhibitor
 +++
HLM Stability
 +++
 
Excretion
CLplasma
 2.847
 
T1/2
 1.385
Toxicity
DILI
 ++
 
Rat Oral Acute Toxicity
 ++
 
FDAMDD
 ++
 
Respiratory
 ++
 
Human Hepatotoxicity
 +
 
Ototoxicity
 -
 
Drug-induced Nephrotoxicity
 +++
 
Drug-induced Neurotoxicity
 +
 
Hematotoxicity
 ++
 
Genotoxicity
 +++
 
Tips: 1. For the classification endpoints, the prediction probability values are transformed into six symbols: 0-0.1 (- - -), 0.1-0.3 (- -), 0.3-0.5 (-), 0.5-0.7 (+), 0.7-0.9 (++), and 0.9-1.0 (+++). 2. Additionally, the corresponding relationships of the three labels are as follows: excellent; medium; poor.
    Click to Show/Hide
    Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product
Formula
C32H46O8
PubChem CID
5281316
Canonical SMILES
CC(=O)OC(C)(C)C=CC(=O)C(C)(C1C(CC2(C1(CC(=O)C3(C2CC=C4C3CC(C(=O)C4(C)C)O)C)C)C)O)O
InChI
1S/C32H46O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-13,19-22,25,34-35,39H,11,14-16H2,1-9H3/b13-12+/t19-,20+,21-,22+,25+,29+,30-,31+,32+/m1/s1
InChIKey
IXQKXEUSCPEQRD-DKRGWESNSA-N
CAS Number
CAS 6199-67-3
ChEBI ID
CHEBI:3941
Herb ID
HBIN021845
SymMap ID
SMIT00503
TCMSP ID
MOL002440
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Doxorubicin      Solid tumour/cancer     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Expression BCL-2  Molecule Info 
Pathway MAP
Down-regulation Expression BIRC5  Molecule Info 
Pathway MAP
Up-regulation Phosphorylation ERK1  Molecule Info 
Pathway MAP
Up-regulation Cleavage PARP1  Molecule Info 
Pathway MAP
                    In-vitro Model 8505C CVCL_1054 Thyroid gland anaplastic carcinoma Homo sapiens
CAL-62 CVCL_1112 Thyroid gland anaplastic carcinoma Homo sapiens
                    Experimental
                    Result(s)		 Doxorubicin has a synergistic cytotoxicity with cucurbitacin B in anaplastic thyroid carcinoma cells.
          Cisplatin      Bladder cancer     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [3]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vitro Model MB49 CVCL_7076 Bladder transitional cell carcinoma Mus musculus
                    In-vivo Model To establish a syngeneic mouse bladder tumor model, 1 * 106 MB49 cells in 100 uL cold PBS were injected subcutaneously into the right flank of the each C57BL/6 mouse strain.
                    Experimental
                    Result(s)		 Cucurbitacin B and cisplatin induce the cell death pathways in MB49 mouse bladder cancer model.
          Gamma-ray irradiation      Brain metastases     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [4]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vitro Model SK-BR-3 CVCL_0033 Breast adenocarcinoma Homo sapiens
MDA-MB-231 CVCL_0062 Breast adenocarcinoma Homo sapiens
MCF-7 CVCL_0031 Invasive breast carcinoma Homo sapiens
                    Experimental
                    Result(s)		 Cucurbitacin B causes increased radiation sensitivity of human breast cancer cells via G2/M cell cycle arrest.
          Gefitinib      Lung cancer     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [5]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    In-vitro Model HCT 116 CVCL_0291 Colon carcinoma Homo sapiens
HT-29 CVCL_0320 Colon adenocarcinoma Homo sapiens
                    Experimental
                    Result(s)		 CuB plus Gef treatment caused a significant growth and cell cycle inhibition and induced apoptosis in both cell lines.
Target and Pathway
Target(s) ATP-citrate synthase (ACLY)  Molecule Info  [6]
Extracellular signal-regulated kinase 1 (ERK1)  Molecule Info  [7]
Extracellular signal-regulated kinase 2 (ERK2)  Molecule Info  [7]
Protein kinase B alpha (AKT1)  Molecule Info  [7]
Serine/threonine-protein kinase mTOR (mTOR)  Molecule Info  [7]
Tyrosine kinase receptor Erbb2 (HER2)  Molecule Info  [8]
BioCyc Acetyl-CoA biosynthesis from citrate Click to Show/Hide
KEGG Pathway MAPK signaling pathway Click to Show/Hide
2 ErbB signaling pathway
3 Ras signaling pathway
4 Rap1 signaling pathway
5 cGMP-PKG signaling pathway
6 cAMP signaling pathway
7 Chemokine signaling pathway
8 HIF-1 signaling pathway
9 FoxO signaling pathway
10 Sphingolipid signaling pathway
11 Oocyte meiosis
12 mTOR signaling pathway
13 PI3K-Akt signaling pathway
14 Adrenergic signaling in cardiomyocytes
15 Vascular smooth muscle contraction
16 Dorso-ventral axis formation
17 TGF-beta signaling pathway
18 Axon guidance
19 VEGF signaling pathway
20 Osteoclast differentiation
21 Focal adhesion
22 Adherens junction
23 Gap junction
24 Signaling pathways regulating pluripotency of stem cells
25 Platelet activation
26 Toll-like receptor signaling pathway
27 NOD-like receptor signaling pathway
28 Natural killer cell mediated cytotoxicity
29 T cell receptor signaling pathway
30 B cell receptor signaling pathway
31 Fc epsilon RI signaling pathway
32 Fc gamma R-mediated phagocytosis
33 TNF signaling pathway
34 Circadian entrainment
35 Long-term potentiation
36 Neurotrophin signaling pathway
37 Retrograde endocannabinoid signaling
38 Glutamatergic synapse
39 Cholinergic synapse
40 Serotonergic synapse
41 Long-term depression
42 Regulation of actin cytoskeleton
43 Insulin signaling pathway
44 GnRH signaling pathway
45 Progesterone-mediated oocyte maturation
46 Estrogen signaling pathway
47 Melanogenesis
48 Prolactin signaling pathway
49 Thyroid hormone signaling pathway
50 Oxytocin signaling pathway
51 Type II diabetes mellitus
52 Aldosterone-regulated sodium reabsorption
53 Alzheimer's disease
54 Prion diseases
55 Alcoholism
56 Shigellosis
57 Salmonella infection
58 Pertussis
59 Leishmaniasis
60 Chagas disease (American trypanosomiasis)
61 Toxoplasmosis
62 Tuberculosis
63 Hepatitis C
64 Hepatitis B
65 Influenza A
66 Pathways in cancer
67 Viral carcinogenesis
68 Proteoglycans in cancer
69 Colorectal cancer
70 Renal cell carcinoma
71 Pancreatic cancer
72 Endometrial cancer
73 Glioma
74 Prostate cancer
75 Thyroid cancer
76 Melanoma
77 Bladder cancer
78 Chronic myeloid leukemia
79 Acute myeloid leukemia
80 Non-small cell lung cancer
81 Central carbon metabolism in cancer
82 Choline metabolism in cancer
83 Calcium signaling pathway
84 MicroRNAs in cancer
85 AMPK signaling pathway
86 Apoptosis
87 Tight junction
88 Jak-STAT signaling pathway
89 Dopaminergic synapse
90 Adipocytokine signaling pathway
91 Glucagon signaling pathway
92 Regulation of lipolysis in adipocytes
93 Non-alcoholic fatty liver disease (NAFLD)
94 Carbohydrate digestion and absorption
95 Measles
96 HTLV-I infection
97 Epstein-Barr virus infection
98 Small cell lung cancer
99 Citrate cycle (TCA cycle)
100 Metabolic pathways
101 Biosynthesis of antibiotics
NetPath Pathway IL5 Signaling Pathway Click to Show/Hide
2 TCR Signaling Pathway
3 TSH Signaling Pathway
4 TGF_beta_Receptor Signaling Pathway
5 IL2 Signaling Pathway
Panther Pathway Alzheimer disease-amyloid secretase pathway Click to Show/Hide
2 Angiogenesis
3 Apoptosis signaling pathway
4 B cell activation
5 EGF receptor signaling pathway
6 Endothelin signaling pathway
7 FGF signaling pathway
8 Inflammation mediated by chemokine and cytokine signaling pathway
9 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
10 Integrin signalling pathway
11 Interferon-gamma signaling pathway
12 Interleukin signaling pathway
13 PDGF signaling pathway
14 Parkinson disease
15 TGF-beta signaling pathway
16 T cell activation
17 Toll receptor signaling pathway
18 VEGF signaling pathway
19 Ras Pathway
20 Angiotensin II-stimulated signaling through G proteins and beta-arrestin
21 CCKR signaling map ST
22 Cadherin signaling pathway
23 Huntington disease
24 Hypoxia response via HIF activation
25 Insulin/IGF pathway-protein kinase B signaling cascade
26 PI3 kinase pathway
27 p53 pathway
28 p53 pathway by glucose deprivation
29 p53 pathway feedback loops 2
Pathwhiz Pathway Phosphatidylinositol Phosphate Metabolism Click to Show/Hide
2 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
3 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
4 Fc Epsilon Receptor I Signaling in Mast Cells
5 Insulin Signalling
6 Leucine Stimulation on Insulin Signaling
7 Transfer of Acetyl Groups into Mitochondria
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells Click to Show/Hide
2 Endothelins
3 BCR signaling pathway
4 Signaling events mediated by PRL
5 ErbB4 signaling events
6 GMCSF-mediated signaling events
7 Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
8 S1P3 pathway
9 EPHB forward signaling
10 Osteopontin-mediated events
11 S1P4 pathway
12 Presenilin action in Notch and Wnt signaling
13 TRAIL signaling pathway
14 CDC42 signaling events
15 Signaling events regulated by Ret tyrosine kinase
16 Angiopoietin receptor Tie2-mediated signaling
17 S1P1 pathway
18 Regulation of Telomerase
19 Netrin-mediated signaling events
20 Role of Calcineurin-dependent NFAT signaling in lymphocytes
21 Glucocorticoid receptor regulatory network
22 Arf6 downstream pathway
23 mTOR signaling pathway
24 IL2-mediated signaling events
25 EGF receptor (ErbB1) signaling pathway
26 Ras signaling in the CD4+ TCR pathway
27 Ceramide signaling pathway
28 Integrins in angiogenesis
29 IFN-gamma pathway
30 ErbB1 downstream signaling
31 ATF-2 transcription factor network
32 ErbB2/ErbB3 signaling events
33 ALK1 signaling events
34 PDGFR-beta signaling pathway
35 Neurotrophic factor-mediated Trk receptor signaling
36 Syndecan-1-mediated signaling events
37 Retinoic acid receptors-mediated signaling
38 Nongenotropic Androgen signaling
39 CXCR3-mediated signaling events
40 VEGFR1 specific signals
41 Regulation of cytoplasmic and nuclear SMAD2/3 signaling
42 Signaling events mediated by Stem cell factor receptor (c-Kit)
43 Signaling events mediated by VEGFR1 and VEGFR2
44 Syndecan-2-mediated signaling events
45 Cellular roles of Anthrax toxin
46 S1P2 pathway
47 Trk receptor signaling mediated by the MAPK pathway
48 Downstream signaling in na&#xef
49
50 VEGFR3 signaling in lymphatic endothelium
51 Alpha-synuclein signaling
52 FGF signaling pathway
53 ErbB receptor signaling network
54 a6b1 and a6b4 Integrin signaling
55 Validated targets of C-MYC transcriptional repression
56 Regulation of nuclear SMAD2/3 signaling
57 LPA receptor mediated events
58 Insulin Pathway
59 IL4-mediated signaling events
60 TCR signaling in na&#xef
61
62 Plasma membrane estrogen receptor signaling
63 CD40/CD40L signaling
64 Signaling events mediated by PTP1B
65 Coregulation of Androgen receptor activity
66 Reelin signaling pathway
67 Integrin-linked kinase signaling
68 TCR signaling in na&#xef
69 FAS (CD95) signaling pathway
70 Thromboxane A2 receptor signaling
71 FOXA2 and FOXA3 transcription factor networks
72 CXCR4-mediated signaling events
73 IGF1 pathway
74 FoxO family signaling
75 IL2 signaling events mediated by PI3K
76 p75(NTR)-mediated signaling
77 E-cadherin signaling in the nascent adherens junction
78 amb2 Integrin signaling
79 IL6-mediated signaling events
80 E-cadherin signaling in keratinocytes
81 Nephrin/Neph1 signaling in the kidney podocyte
82 IL8- and CXCR2-mediated signaling events
83 Signaling events mediated by the Hedgehog family
84 Hedgehog signaling events mediated by Gli proteins
85 Caspase Cascade in Apoptosis
86 Aurora A signaling
87 Insulin-mediated glucose transport
88 Class I PI3K signaling events mediated by Akt
89 IL8- and CXCR1-mediated signaling events
90 HIF-1-alpha transcription factor network
91 p53 pathway
92 Trk receptor signaling mediated by PI3K and PLC-gamma
93 Class IB PI3K non-lipid kinase events
94 BMP receptor signaling
95 Signaling events mediated by focal adhesion kinase
96 IL12-mediated signaling events
97 LKB1 signaling events
98 EGFR-dependent Endothelin signaling events
Reactome MAPK3 (ERK1) activation Click to Show/Hide
2 RAF-independent MAPK1/3 activation
3 ISG15 antiviral mechanism
4 ERK/MAPK targets
5 Regulation of actin dynamics for phagocytic cup formation
6 Oxidative Stress Induced Senescence
7 Senescence-Associated Secretory Phenotype (SASP)
8 Oncogene Induced Senescence
9 FCERI mediated MAPK activation
10 Regulation of HSF1-mediated heat shock response
11 NCAM signaling for neurite out-growth
12 Activation of the AP-1 family of transcription factors
13 Thrombin signalling through proteinase activated receptors (PARs)
14 Negative regulation of FGFR1 signaling
15 Negative regulation of FGFR2 signaling
16 Negative regulation of FGFR3 signaling
17 Negative regulation of FGFR4 signaling
18 RHO GTPases Activate WASPs and WAVEs
19 RAF/MAP kinase cascade
20 MAP2K and MAPK activation
21 Negative feedback regulation of MAPK pathway
22 Negative regulation of MAPK pathway
23 Signal attenuation
24 Advanced glycosylation endproduct receptor signaling
25 Gastrin-CREB signalling pathway via PKC and MAPK
26 Growth hormone receptor signaling
27 SHC1 events in ERBB2 signaling
28 PLCG1 events in ERBB2 signaling
29 PIP3 activates AKT signaling
30 GRB2 events in ERBB2 signaling
31 PI3K events in ERBB2 signaling
32 Constitutive Signaling by Aberrant PI3K in Cancer
33 Sema4D induced cell migration and growth-cone collapse
34 Activation of BAD and translocation to mitochondria
35 GPVI-mediated activation cascade
36 Translocation of GLUT4 to the plasma membrane
37 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
38 AKT phosphorylates targets in the cytosol
39 AKT phosphorylates targets in the nucleus
40 Negative regulation of the PI3K/AKT network
41 eNOS activation
42 AKT-mediated inactivation of FOXO1A
43 Integrin alphaIIb beta3 signaling
44 Deactivation of the beta-catenin transactivating complex
45 CD28 dependent PI3K/Akt signaling
46 CTLA4 inhibitory signaling
47 G beta:gamma signalling through PI3Kgamma
48 KSRP (KHSRP) binds and destabilizes mRNA
49 VEGFR2 mediated vascular permeability
50 TP53 Regulates Metabolic Genes
51 Constitutive Signaling by AKT1 E17K in Cancer
52 ChREBP activates metabolic gene expression
53 Fatty Acyl-CoA Biosynthesis
54 MAPK1 (ERK2) activation
55 Golgi Cisternae Pericentriolar Stack Reorganization
56 Recycling pathway of L1
57 CREB phosphorylation through the activation of Ras
58 Macroautophagy
59 mTORC1-mediated signalling
60 HSF1-dependent transactivation
WikiPathways Toll-like receptor signaling pathway Click to Show/Hide
2 Serotonin Receptor 4/6/7 and NR3C Signaling
3 Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
4 Serotonin HTR1 Group and FOS Pathway
5 TCR Signaling Pathway
6 Hypothetical Network for Drug Addiction
7 EPO Receptor Signaling
8 TGF Beta Signaling Pathway
9 Regulation of Actin Cytoskeleton
10 IL-2 Signaling Pathway
11 Insulin Signaling
12 MAPK Cascade
13 IL-4 Signaling Pathway
14 MAPK Signaling Pathway
15 IL-6 signaling pathway
16 Signaling of Hepatocyte Growth Factor Receptor
17 Kit receptor signaling pathway
18 TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
19 IL-3 Signaling Pathway
20 Cardiac Hypertrophic Response
21 MAP kinase activation in TLR cascade
22 Fc epsilon receptor (FCERI) signaling
23 RAF/MAP kinase cascade
24 Structural Pathway of Interleukin 1 (IL-1)
25 Genes and (Common) Pathways Underlying Drug Addiction
26 Signal Transduction of S1P Receptor
27 PDGF Pathway
28 Alpha 6 Beta 4 signaling pathway
29 Spinal Cord Injury
30 BDNF signaling pathway
31 Integrated Pancreatic Cancer Pathway
32 Oncostatin M Signaling Pathway
33 Corticotropin-releasing hormone
34 Interleukin-11 Signaling Pathway
35 AGE/RAGE pathway
36 TNF alpha Signaling Pathway
37 Prostate Cancer
38 Signaling Pathways in Glioblastoma
39 TSLP Signaling Pathway
40 IL-9 Signaling Pathway
41 IL17 signaling pathway
42 Alzheimers Disease
43 IL-7 Signaling Pathway
44 TWEAK Signaling Pathway
45 FSH signaling pathway
46 Leptin signaling pathway
47 RANKL/RANK Signaling Pathway
48 IL-1 signaling pathway
49 Thrombin signalling through proteinase activated receptors (PARs)
50 Signaling by Insulin receptor
51 Signaling by FGFR
52 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
53 L1CAM interactions
54 Advanced glycosylation endproduct receptor signaling
55 Apoptosis Modulation and Signaling
56 MicroRNAs in cardiomyocyte hypertrophy
57 Regulation of toll-like receptor signaling pathway
58 Osteopontin Signaling
59 IL-5 Signaling Pathway
60 DNA Damage Response (only ATM dependent)
61 ErbB Signaling Pathway
62 EGF/EGFR Signaling Pathway
63 Focal Adhesion
64 Extracellular vesicle-mediated signaling in recipient cells
65 Bladder Cancer
66 Signaling by ERBB2
67 miR-targeted genes in muscle cell - TarBase
68 Semaphorin interactions
69 Notch Signaling Pathway
70 Endochondral Ossification
71 TGF beta Signaling Pathway
72 Wnt Signaling Pathway Netpath
73 Copper homeostasis
74 Apoptosis-related network due to altered Notch3 in ovarian cancer
75 Translocation of GLUT4 to the Plasma Membrane
76 Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
77 PIP3 activates AKT signaling
78 T-Cell Receptor and Co-stimulatory Signaling
79 Primary Focal Segmental Glomerulosclerosis FSGS
80 Apoptosis
81 B Cell Receptor Signaling Pathway
82 Regulation of Microtubule Cytoskeleton
83 TSH signaling pathway
84 Integrated Breast Cancer Pathway
85 SREBP signalling
86 Integrated Cancer pathway
87 Metabolism of nitric oxide
88 Integrin-mediated Cell Adhesion
89 TFs Regulate miRNAs related to cardiac hypertrophy
90 Angiogenesis
91 TOR Signaling
92 AMPK Signaling
93 Androgen receptor signaling pathway
94 Fatty Acid Biosynthesis
95 TCA Cycle and PDHc
96 Butyrate-induced histone acetylation
97 Integration of energy metabolism
98 Fatty acid, triacylglycerol, and ketone body metabolism
99 Vitamin A and Carotenoid Metabolism
100 Senescence and Autophagy in Cancer
101 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
102 Nanoparticle-mediated activation of receptor signaling
103 EBV LMP1 signaling
104 Nifedipine Activity
105 Aryl Hydrocarbon Receptor
106 Endothelin Pathways
107 Opioid Signalling
108 Heart Development
109 Type II diabetes mellitus
110 Physiological and Pathological Hypertrophy of the Heart
111 Interferon type I signaling pathways
112 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
113 Polycystic Kidney Disease Pathway
114 SREBF and miR33 in cholesterol and lipid homeostasis
115 Costimulation by the CD28 family
References
Reference 1 Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity. Arch Biochem Biophys. 2020 May 15;684:108314.
Reference 2 Doxorubicin has a synergistic cytotoxicity with cucurbitacin B in anaplastic thyroid carcinoma cells. Tumour Biol. 2017 Feb;39(2):1010428317692252.
Reference 3 Cucurbitacin B and cisplatin induce the cell death pathways in MB49 mouse bladder cancer model. Exp Biol Med (Maywood). 2020 May;245(9):805-814.
Reference 4 Cucurbitacin B Causes Increased Radiation Sensitivity of Human Breast Cancer Cells via G2/M Cell Cycle Arrest. J Oncol. 2012;2012:601682.
Reference 5 Treatment with cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via EGFR and JAK/STAT pathway in human colorectal cancer cell lines. Hum Exp Toxicol. 2016 May;35(5):526-43.
Reference 6 Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth. Cancer Lett. 2014 Jul 10;349(1):15-25.
Reference 7 Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma. Cancer Lett. 2011 Jul 28;306(2):161-170.
Reference 8 HER2 mediated de novo production of TGFBeta leads to SNAIL driven epithelial-to-mesenchymal transition and metastasis of breast cancer. Mol Oncol. 2014 Dec;8(8):1532-47.
 Download Picture         KEGG Link      
 Download Picture         KEGG Link      
 Download Picture         KEGG Link      
 Download Picture         KEGG Link      
 Download Picture         KEGG Link