Drug Combination Details
| General Information of the Combination (ID: C03344) | |||||
|---|---|---|---|---|---|
| Name | Curcumin NP Info | + | 1,25-dihydroxyvitamin D3 Drug Info | ||
| Structure |
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+ |
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| Disease |
Breast cancer
[ICD-11: 2C60]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CYP24A1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CYP27B1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | GPX1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | ITGB3 | Molecule Info |
Pathway MAP
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| In-vitro Model | MBCDF | Breast cancer | Homo sapiens | |||
| Experimental
Result(s) |
The concomitant administration of calcitriol with curcumin synergistically promoted anticancer effects in vitro and in vivo. | |||||
