Drug Combination Details
| General Information of the Combination (ID: C03662) | |||||
|---|---|---|---|---|---|
| Name | Allicin NP Info | + | 5-fluorouracil Drug Info | ||
| Structure |
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+ |
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| Disease |
Hepatocellular carcinoma
[ICD-11: 2C12]
|
Investigative | [1] | ||
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Lung cancer
[ICD-11: 2C25]
|
Investigative | [2] | |||
|
Colorectal cancer
[ICD-11: 2B91]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| In-vitro Model | SK-MES-1 | CVCL_0630 | Lung squamous cell carcinoma | Homo sapiens | ||
| DLD-1 | CVCL_0248 | Colon adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
The synergistic antitumor effect of 5-FU combined with allicin was visible against lung and colorectal carcinoma cells. Better results were obtained when a lower concentration of 5-FU was combined with allicin than the single-agent treatment at IC50. | |||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Biological
Regulation |
Induction | Loss of mitochondrial membrane potential | ||||
| Up-regulation | ROS generation | |||||
| In-vitro Model | SK-HEP-1 | CVCL_0525 | Hepatocellular carcinoma | Homo sapiens | ||
| BEL-7402 | CVCL_5492 | Human hepatocellular carcinoma | Homo sapiens | |||
| In-vivo Model | Male athymic nude mice (4-6-week) were injected subcutaneously into left flank with 1*107 GFP-SK-Hep-1 cells. | |||||
| Experimental
Result(s) |
Allicin sensitizes hepatocellular cancer cells to anti-tumor activity of 5-fluorouracil through ROS-mediated mitochondrial pathway. | |||||
